Overview

  • Product name

    Cytostatin, PP2A inhibitor
  • Description

    Potent, selective PP2A inhibitor. Cell adhesion inhibitor.
  • Biological description

    Potent, selective protein phosphatase 2A (PP2A) inhibitor. Cell adhesion inhibitor. Inhibits the adhesion of B16 melanoma cells to laminin and collagen type IV in a dose dependent manner but not to fibronectin. Antitumor agent. Antimetastatic. Apoptosis inducer.
  • Purity

    > 75%
  • CAS Number

    156856-30-3
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Mori N  et al. Protein phosphatase 2A as a potential target for treatment of adult T cell leukemia. Curr Cancer Drug Targets 13:829-42 (2013). Read more (PubMed: 24015987) »
  • Swingle MR  et al. Structure-activity relationship studies of fostriecin, cytostatin, and key analogs, with PP1, PP2A, PP5, and( beta12-beta13)-chimeras (PP1/PP2A and PP5/PP2A), provide further insight into the inhibitory actions of fostriecin family inhibitors. J Pharmacol Exp Ther 331:45-53 (2009). Read more (PubMed: 19592665) »
  • Kawada M  et al. Specific inhibitors of protein phosphatase 2A inhibit tumor metastasis through augmentation of natural killer cells. Int Immunopharmacol 3:179-88 (2003). Read more (PubMed: 12586599) »

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab144235.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

Sign up