D-(+)-Glucosamine hydrochloride, Posttranslational modification regulator (ab143628)

Overview

  • Product name

    D-(+)-Glucosamine hydrochloride, Posttranslational modification regulator
  • Description

    Posttranslational modification regulator
  • Biological description

    Posttranslational modification regulator. Inhibits N-glycosylation of certain proteins. Regulates TGF-β signaling. Downregulates HIF-1. Suppresses 5-HT-induced nociceptive responses. Shows analgesic effects in vivo. Orally active.
  • Purity

    > 96%
  • CAS Number

    66-84-2
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (3R,4R,5S,6R)-3-Amino-6-(hydroxymethyl)oxane-2,4,5-triol hydrochloride
  • Molecular weight

    215.60
  • Molecular formula

    C6H13NO5.HCl
  • PubChem identifier

    2723635
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 10 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C(C1C(C(C(C(O1)O)N)O)O)O.Cl
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Jo JR  et al. Short-term treatment with glucosamine hydrochloride specifically downregulates hypoxia-inducible factor-1a at the protein level in YD-8 human tongue cancer cells. Int J Oncol 44:1699-706 (2014). Read more (PubMed: 24626348) »
  • Kaida K  et al. Suppressive effects of D-glucosamine on the 5-HT sensitive nociceptive units in the rat tooth pulpal nerve. Biomed Res Int 2014:187989 (2014). Read more (PubMed: 24818130) »
  • Park J  et al. Glucosamine hydrochloride exerts a protective effect against unilateral ureteral obstruction-induced renal fibrosis by attenuating TGF-ß signaling. J Mol Med (Berl) 91:1273-84 (2013). Read more (PubMed: 24072041) »

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