Overview

  • Product name

    D-AP5 (mM/ml), NMDA glutamate site antagonist
  • Description

    NMDA glutamate site antagonist. 1 ml water soluble pack.
  • Alternative names

    • APV
    • D-APV
  • Biological description

    Competitive NMDA receptor glutamate site antagonist. More active form of DL-AP5.

    Soluble in 1 ml water to give specified mM/ml concentration. Find out more.
  • Purity

    > 99%
  • CAS Number

    79055-68-8
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    D-(-)-2-Amino-5-phosphonopentanoic acid
  • Molecular weight

    197.13
  • Molecular formula

    C5H12NO5P
  • PubChem identifier

    135342
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in 1 ml of water to give specified mM/ml concentration
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    N[C@H](CCCP(=O)(O)O)C(=O)O
  • Source

    Synthetic

  • Research areas

Images

  • Fractional current mediated by AMPARs increases between birth and hearing onset.

    A: Representative mixed glutamatergic responses from P1, P5 and P9 neurons (average of 10 recordings), scaled to peak AMPA current; distinct AMPA and NMDA components visible in each trace. B: Same traces as in A, showing the mixed glutamatergic current, the pharmacologically isolated NMDAR component, and the response after application of AMPAR and NMDAR antagonists, D-APV and CNQX, which abolishes the glutamatergic response. All recordings in Mg++-free ACSF. Note change in scalebars for P9 recordings. C: Ratios of peak AMPA/NMDA current in 39 cells from slices P1-P12. During this period, AMPA/NMDA ratio increases as a function of age (p = 0.012, Kruskal-Wallis; P1/2 vs P9/10, p = 0.048; P7/8 vs P9/10, p = 0.30; P9/10 vs P11/12 p = 0.010; linear regression slope 0.14/day, r2 = 0.32; exponential fit r2 = 0.36). Filled black circles represent means ± SEMs at two-day intervals. Filled gray circles represent cells shown in A,B. D: Increase in AMPA/NMDA ratio with age is accompanied by small increases in average AMPA current (open circles, regressed to gray line) and decreases in average NMDAR current (filled circles, regressed to black line).

References

This product has been referenced in:

  • Kew JN & Kemp JA Ionotropic and metabotropic glutamate receptor structure and pharmacology. Psychopharmacology (Berl) 179:4-29 (2005). Read more (PubMed: 15731895) »
  • Davies J & Watkins JC Actions of D and L forms of 2-amino-5-phosphonovalerate and 2-amino-4-phosphonobutyrate in the cat spinal cord. Brain Res 235:378-86 (1982). Read more (PubMed: 6145492) »
  • Evans RH  et al. The effects of a series of omega-phosphonic alpha-carboxylic amino acids on electrically evoked and excitant amino acid-induced responses in isolated spinal cord preparations. Br J Pharmacol 75:65-75 (1982). Read more (PubMed: 7042024) »
See all 100 Publications for this product

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab144482.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

Sign up