Overview

  • Product name

    D-erythro-Dihydrosphingosine-1-phosphate, sphingosine 1-phosphate receptor ligand
  • Description

    Potent sphingosine 1-phosphate receptor ligand
  • Biological description

    Sphingosine 1-phosphate (S1P) receptor ligand (Ki = 15 nM). May be used as negative control for intracellular effects of S1P (ab141748). Anti-fibrotic effect in fibroblasts.
  • Purity

    > 98%
  • CAS Number

    28508-07-8
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    [(2S,3R)-2-Amino-3-hydroxyoctadecyl] dihydrogen phosphate
  • Molecular weight

    381.50
  • Molecular formula

    C18H40NO5P
  • PubChem identifier

    644260
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CCCCCCCCCCCCCCCC(C(COP(=O)(O)O)N)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Bu S  et al. Dihydrosphingosine 1-phosphate has a potent antifibrotic effect in scleroderma fibroblasts via normalization of phosphatase and tensin homolog levels. Arthritis Rheum 62:2117-26 (2010). Read more (PubMed: 20309867) »
  • Van Brocklyn JR  et al. Dual actions of sphingosine-1-phosphate: extracellular through the Gi-coupled receptor Edg-1 and intracellular to regulate proliferation and survival. J Cell Biol 142:229-40 (1998). Read more (PubMed: 9660876) »
  • Boumendjel A & Miller SP Synthesis of sphingosine-1-phosphate and dihydrosphingosine-1-phosphate. J Lipid Res 35:2305-11 (1994). Read more (PubMed: 7897327) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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