Overview

  • Product name

    D-erythro MAPP, alkaline ceramidase inhibitor
  • Description

    Specific alkaline ceramidase inhibitor
  • Biological description

    Specific inhibitor of alkaline ceramidase (IC50 = 1 μM). Elevates endogenous ceramide leading to growth suppression and cell cycle arrest. Inhibits acid ceramidase (IC50 = 500 μM). Cell-permeable. Active in vitro.
  • Purity

    > 98%
  • CAS Number

    143492-38-0
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    N-[(1S,2R)-1-Hydroxy-1-phenylpropan-2-yl]tetradecanamide
  • Molecular weight

    361.60
  • Molecular formula

    C23H39NO2
  • PubChem identifier

    124735
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 50 mM and in ethanol to 50 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CCCCCCCCCCCCCC(=O)NC(C)C(C1=CC=CC=C1)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Shimizu M  et al. Effects of ceramide, ceramidase inhibition and expression of ceramide kinase on cytosolic phospholipase A2alpha; additional role of ceramide-1-phosphate in phosphorylation and Ca2+ signaling. Cell Signal 21:440-7 (2009). Read more (PubMed: 19101626) »
  • Choi MS  et al. Neutral ceramidase gene: role in regulating ceramide-induced apoptosis. Gene 315:113-22 (2003). Read more (PubMed: 14557071) »
  • Bielawska A  et al. (1S,2R)-D-erythro-2-(N-myristoylamino)-1-phenyl-1-propanol as an inhibitor of ceramidase. J Biol Chem 271:12646-54 (1996). Read more (PubMed: 8647877) »

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