Overview

  • Product name

    D-Penicillamine, Copper chelator
  • Description

    Copper chelator. Structural analog of cysteine.
  • Biological description

    Copper chelator. Structural analog of cysteine and metabolite of penicillin. Displays a variety of biological effects. Acts as an immunosuppressant and shows antirheumatic effect. Active in vivo.
  • Purity

    > 97%
  • CAS Number

    52-67-5
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Sharifian M  et al. D-penicillamine, a potent melanogenesis inhibitor, lacks any depigmenting effect on black guinea pig skin: the first randomized, evaluator-blinded, vehicle-controlled, in vivo study. Acta Dermatovenerol Alp Panonica Adriat 20:51-3 (2011). Read more (PubMed: 21993701) »
  • Gupte A & Mumper RJ Copper chelation by D-penicillamine generates reactive oxygen species that are cytotoxic to human leukemia and breast cancer cells. Free Radic Biol Med 43:1271-8 (2007). Read more (PubMed: 17893040) »
  • de Groot-Besseling RR  et al. Angiostatin generating capacity and anti-tumour effects of D-penicillamine and plasminogen activators. BMC Cancer 6:149 (2006). Read more (PubMed: 16753063) »
  • Lipsky PE Immunosuppression by D-penicillamine in vitro. Inhibition of human T lymphocyte proliferation by copper- or ceruloplasmin-dependent generation of hydrogen peroxide and protection by monocytes. J Clin Invest 73:53-65 (1984). Read more (PubMed: 6606652) »

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