D-threo-PPMP (PPMP), glucosylceramide synthase inhibitor (ab144104)

Overview

  • Product name

    D-threo-PPMP (PPMP), glucosylceramide synthase inhibitor
  • Description

    Endogenous glucosylceramide synthase inhibitor
  • Alternative names

    • D-threo-1-Phenyl-2-hexadecanoylamino-3-morpholino-1-propanol•HCl Activity: glucosylceramide synthase inhibitor
  • Purity

    > 98%
  • CAS Number

    139889-53-5
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    N-[(1R,2R)-2-Hydroxy-1-(4-morpholinylmethyl)-2-phenylethyl]hexadecanamide hydrochloride

  • Molecular weight

    511.18
  • Molecular formula

    C29H50N2O3.HCl
  • PubChem identifier

    3008318
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol, methanol

  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    Cl.CCCCCCCCCCCCCCCC(=O)N[C@H](CN1CCOCC1)[C@H](O)c2ccccc2
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Hernandez Y  et al. Novel role of sphingolipid synthesis genes in regulating giardial encystation. Infect Immun 76:2939-49 (2008). Read more (PubMed: 18426892) »
  • Wu X  et al. Liquid chromatography method for quantifying D-threo-1-phenyl-2-palmitoylamino-3-morpholino-1-propanol (D-threo-PPMP) in mouse plasma and liver. J Chromatogr B Analyt Technol Biomed Life Sci 837:44-8 (2006). Read more (PubMed: 16716770) »
  • Kovács P  et al. Effect of glucosphingolipid synthesis inhibitor (PPMP and PDMP) treatment on Tetrahymena pyriformis: data on the evolution of the signaling system. Cell Biochem Funct 18:269-80 (2000). Read more (PubMed: 11180290) »

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab144104.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

Sign up