Overview

  • Product name

    [D-Trp6]-LH-RH, LHRH and GnRH agonist
  • Description

    LHRH and GnRH agonist
  • Biological description

    Luteinizing hormone- and gonadotropin- releasing hormone agonist. Antineoplastic and luteolytic agent. Active in vivo and in vitro.
  • Purity

    > 98%
  • CAS Number

    57773-63-4
  • Chemical structure

    Chemical Structure

Properties

  • Molecular weight

    1311.50
  • Molecular formula

    C64H82N18O13
  • Sequence

    XHWSYWLRPG (Modifications: C-terminal amide; X-1 = Glp; Trp-6 = D-Trp)
  • PubChem identifier

    25074470
  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(C)C[C@@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N)NC(=O)[C@@H](Cc2c[nH]c3c2cccc3)NC(=O)[C@H](Cc4ccc(cc4)O)NC(=O)[C@H](CO)NC(=O)[C@H](Cc5c[nH]c6c5cccc6)NC(=O)[C@H](Cc7cnc[nH]7)NC(=O)[C@@H]8CCC(=O)N8
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Juszczak M & Roszczyk M Oxytocin and vasopressin secretion from the rat hypothalamo-neurohypophysial system is stimulated by triptorelin. Endokrynol Pol 63:176-81 (2012). Read more (PubMed: 22744622) »
  • Pelletier G  et al. Role of extra-ovarian oestrogens in the regulation of gonadotropin releasing hormone mRNA expression in the rat brain. J Neuroendocrinol 13:678-82 (2001). Read more (PubMed: 11489084) »
  • Torres-Aleman I  et al. Effect of [D-Trp6]LHRH infusion on prolactin secretion by perifused rat pituitary cells. Regul Pept 18:19-28 (1987). Read more (PubMed: 2957725) »

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