Overview

  • Product name

    Anti-D2HGDH antibody - C-terminal
    See all D2HGDH primary antibodies
  • Description

    Rabbit polyclonal to D2HGDH - C-terminal
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Horse
  • Immunogen

    Synthetic peptide corresponding to a region within C terminal amino acids 332-381 (QESPFYVLIE TSGSNAGHDA EKLGHFLEHA LGSGLVTDGT MATDQRKVKM) of Human D2HGDH (NP_689996).

  • Positive control

    • PANC1 cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab136336 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 56 kDa.

Target

  • Relevance

    Catalyzes the oxidation of D-2-hydroxyglutarate to alpha-ketoglutarate. Disease: Defects in D2HGDH are the cause of D-2-hydroxyglutaric aciduria type 1 (D2HGA1) [MIM:600721]. D2HGA1 is a rare recessive neurometabolic disorder causing developmental delay, epilepsy, hypotonia, and dysmorphic features. Both a mild and a severe phenotype exist. The severe phenotype is homogeneous and is characterized by early infantile-onset epileptic encephalopathy and cardiomyopathy. The mild phenotype has a more variable clinical presentation. Diagnosis is based on the presence of an excess of D-2-hydroxyglutaric acid in the urine. Similarity: Belongs to the FAD-binding oxidoreductase/transferase type 4 family. Contains 1 FAD-binding PCMH-type domain.
  • Database links

  • Alternative names

    • D-2-hydroxyglutarate dehydrogenase antibody
    • D-2-hydroxyglutarate dehydrogenase, mitochondrial antibody
    • D2HGD antibody
    • D2hgdh antibody

Images

  • Anti-D2HGDH antibody - C-terminal (ab136336) at 1 µg/ml + PANC1 cell lysate at 10 µg

    Predicted band size: 56 kDa

References

ab136336 has not yet been referenced specifically in any publications.

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