Daminozide, histone demethylase KDM2/7 subfamily inhibitor (ab144621)

Overview

  • Product name

    Daminozide, histone demethylase KDM2/7 subfamily inhibitor
  • Description

    Selective histone demethylase KDM2/7 subfamily inhibitor
  • Alternative names

    • Succinic acid mono(2,2-dimethylhydrazide)
  • Biological description

    Selective histone demethylase KDM2/7 subfamily inhibitor (IC50 values are 0.55, 1.5 and 2.1 μM for PHF8, KDM2A and KDM7A respectively). Exhibits ≥ 60-fold selectivity for KDM2/7 demethylases over other histone demethylases (KDM3, KDM4, KDM5, KDM6) and 2-oxoglurate oxygenases (FIH, PHD2, BBOX1) (IC50 values >100 μM). Active in vitro. Cell-permeable.

  • Purity

    > 98%
  • CAS Number

    1596-84-5
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    1-(2,2-Dimethylhydrazide)butanedioic acid
  • Molecular weight

    160.17
  • Molecular formula

    C6H12N2O3
  • PubChem identifier

    15331
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 100 mM and in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CN(C)NC(=O)CCC(=O)O
  • Source

    Synthetic

References

This product has been referenced in:

  • Rose NR  et al. Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases. J Med Chem 55:6639-43 (2012). Read more (PubMed: 22724510) »
  • Yan S  et al. Quartz crystal microbalance for the determination of daminozide using molecularly imprinted polymers as recognition element. Biosens Bioelectron 22:1087-91 (2007). Read more (PubMed: 16621501) »

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