Anti-DAP Kinase 1 antibody (ab200549)
Key features and details
- Rabbit polyclonal to DAP Kinase 1
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-DAP Kinase 1 antibody -
Description
Rabbit polyclonal to DAP Kinase 1 -
Host species
Rabbit -
Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Dog, Rhesus monkey -
Immunogen
Recombinant fragment within Human DAP Kinase 1 aa 38-374. The exact sequence is proprietary. NP_004929.2.
Database link: P53355 -
Positive control
- Human Placenta tissue.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 20% Glycerol (glycerin, glycerine), 79% Tris glycine -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab200549 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
IHC-P |
Use a concentration of 5 - 10 µg/ml.
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Notes |
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IHC-P
Use a concentration of 5 - 10 µg/ml. |
Target
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Function
Calcium/calmodulin-dependent serine/threonine kinase which acts as a positive regulator of apoptosis. -
Sequence similarities
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily.
Contains 10 ANK repeats.
Contains 1 death domain.
Contains 1 protein kinase domain. -
Post-translational
modificationsUbiquitinated by the BCR(KLHL20) E3 ubiquitin ligase complex, leading to its degradation by the proteasome. -
Cellular localization
Cytoplasm. Colocalizes with the actin filament system. - Information by UniProt
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Database links
- Entrez Gene: 484142 Dog
- Entrez Gene: 1612 Human
- Entrez Gene: 694315 Rhesus monkey
- Omim: 600831 Human
- SwissProt: P53355 Human
- Unigene: 380277 Human
- Unigene: 693441 Human
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Alternative names
- DAK1 antibody
- DAP K1 antibody
- DAP kinase 1 antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (3)
ab200549 has been referenced in 3 publications.
- Zhang J et al. Death-Associated Protein Kinase 1 (DAPK1) Protects against Myocardial Injury Induced by Myocardial Infarction in Rats via Inhibition of Inflammation and Oxidative Stress. Dis Markers 2022:9651092 (2022). PubMed: 35082934
- Guo Z et al. Extracellular vesicle-encapsulated microRNA-425-derived from drug-resistant cells promotes non-small-cell lung cancer progression through DAPK1-medicated PI3K/AKT pathway. J Cell Physiol 236:3808-3820 (2021). PubMed: 33258116
- Prokesch A et al. Placental DAPK1 and autophagy marker LC3B-II are dysregulated by TNF-a in a gestational age-dependent manner. Histochem Cell Biol 147:695-705 (2017). PubMed: 28097431