Overview

  • Product name

    Daphnetin, Protein kinase inhibitor
  • Description

    Protein kinase inhibitor; EGFR, PKA and PKC
  • Biological description

    Protein kinase inhibitor (IC50 values are 7.67, 9.33 and 25.01 μM for EGFR, PKA and PKC respectively). Inhibits EGFR competitively to ATP and non-competitively to the peptide substrate. Coumarin (ab142628) derivative. Shows analgesic, antimalarial, antiarthritic, and antipyretic effects in vivo.
  • CAS Number

    486-35-1
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Du G  et al. Daphnetin, a natural coumarin derivative, provides the neuroprotection against glutamate-induced toxicity in HT22 cells and ischemic brain injury. Neurochem Res 39:269-75 (2014). Read more (PubMed: 24343531) »
  • Liu ZY  et al. Protective effects of daphnetin on sodium taurocholate-induced severe acute pancreatitis in rats. Mol Med Rep 9:1709-14 (2014). Read more (PubMed: 24584301) »
  • Fylaktakidou KC  et al. Natural and synthetic coumarin derivatives with anti-inflammatory/ antioxidant activities. Curr Pharm Des 10:3813-33 (2004). Read more (PubMed: 15579073) »

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