Overview

  • Product name

    Daptomycin, Lipopeptide antibiotic
  • Description

    Lipopeptide antibiotic
  • Alternative names

    • LY146032
  • Biological description

    Lipopeptide antibiotic. Gram-positive bacterial membrane integrity antagonist. Does not interact with p450 cytochromes. Concentration-dependent antibacterial activity in vitro and in vivo.
  • Purity

    > 97%
  • CAS Number

    103060-53-3
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    S)-N-(1-Oxodecyl)-L-tryptophyl-D-asparaginyl-L-α-aspartyl-L-threonylglycyl-L-ornithyl-L-α-aspartyl-D-alanyl-L-α-aspartylglycyl-D-seryl-(3R)-3-methyl-L-α-glutamyl-α,2-diamino-γ-oxobenzenebutanoic acid (13-4) lactone
  • Molecular weight

    1620.69
  • Molecular formula

    C72H101N17O26
  • PubChem identifier

    16129629
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    NC(=O)C[C@H](NC(=O)[C@H](Cc1cnc2ccccc12)NC(=O)CCCCCCCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H]4C(=O)NCC(=O)N[C@@H](CCCN)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@H](CO)C(=O)N[C@@H]([C@H](C)CC(=O)O)C(=O)N[C@@H](CC(=O)c3ccccc3N)C(=O)O[C@@H]4C
  • Source

    Steptomyces nouseri

  • Research areas

References

This product has been referenced in:

  • Kosmidis C & Levine DP Daptomycin: pharmacology and clinical use. Expert Opin Pharmacother 11:615-25 (2010). Read more (PubMed: 20163272) »
  • Steenbergen JN  et al. Effects of daptomycin in combination with other antimicrobial agents: a review of in vitro and animal model studies. J Antimicrob Chemother 64:1130-8 (2009). Read more (PubMed: 19825818) »

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