Overview

  • Product name

    Darifenacin Hydrobromide, M3 antagonist
  • Description

    Potent and selective M3 antagonist
  • Biological description

    Potent and selective M3 antagonist (Ki values are 0.79, 2.3, 5.01, 7.94 and 25.1 nM for M3, M5, M1, M2 and M4 respectively). Shows anticholinergic effects and inhibits bladder contractions in vivo. Orally active.
  • Purity

    > 99%
  • CAS Number

    133099-07-7
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2-[(3S)-1-[2-(2,3-Dihydro-1-benzofuran-5-yl)ethyl]pyrrolidin-3-yl]-2,2-diphenylacetamide hydrobromide
  • Molecular weight

    507.46
  • Molecular formula

    C28H30N2O2.HBr
  • PubChem identifier

    444030
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble to 100 mM in DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1CN(CC1C(C2=CC=CC=C2)(C3=CC=CC=C3)C(=O)N)CCC4=CC5=C(C=C4)OCC5.Br
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Matsumoto Y  et al. Role of M2 and M3 muscarinic acetylcholine receptor subtypes in activation of bladder afferent pathways in spinal cord injured rats. Urology 79:1184.e15-20 (2012). Read more (PubMed: 22386753) »
  • Hahn M  et al. Atypical antipsychotics and effects of muscarinic, serotonergic, dopaminergic and histaminergic receptor binding on insulin secretion in vivo: an animal model. Schizophr Res 131:90-5 (2011). Read more (PubMed: 21696923) »
  • Md Anisuzzaman AS  et al. Influence of tissue integrity on pharmacological phenotypes of muscarinic acetylcholine receptors in the rat cerebral cortex. J Pharmacol Exp Ther 339:186-93 (2011). Read more (PubMed: 21719469) »

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab143021.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

Sign up