Overview

  • Product name

    Dasatinib,  Src family tyrosine kinase (SFK)/Bcl-Abl kinase inhibitor
  • Description

    Potent Src family tyrosine kinase (SFK)/Bcl-Abl kinase inhibitor
  • Alternative names

    • BMS 354825
    • BMS354825
    • Sprycel
  • Biological description

    Potent Src family tyrosine kinase (SFK)/Bcl-Abl kinase inhibitor. Inhibits growth of Bcr-Abl–dependent chronic myeloid leukemia xenografts in nude mice. Anti-tumor activity in vivo.

  • Purity

    > 98%
  • CAS Number

    302962-49-8
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]-1,3-thiazole-5-carboxamide
  • Molecular weight

    488.01
  • Molecular formula

    C22H26ClN7O2S
  • PubChem identifier

    3062316
  • Storage instructions

    Shipped at Room Temperature. Store at -20°C. Store under desiccating conditions.
  • Solubility overview

    Soluble in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1=C(C(=CC=C1)Cl)NC(=O)C2=CN=C(S2)NC3=NC(=NC(=C3)N4CCN(CC4)CCO)C
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Sievers E  et al. SRC inhibition represents a potential therapeutic strategy in liposarcoma. Int J Cancer 137:2578-88 (2015). Read more (PubMed: 26084847) »
  • Aguilera DG & Tsimberidou AM Dasatinib in chronic myeloid leukemia: a review. Ther Clin Risk Manag 5:281-9 (2009). Read more (PubMed: 19536317) »
  • Das J  et al. 2-aminothiazole as a novel kinase inhibitor template. Structure-activity relationship studies toward the discovery of N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1- piperazinyl)]-2-methyl-4-pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide (dasatinib, BMS-354825) as a potent pan-Src kinase inhibitor. J Med Chem 49:6819-32 (2006). Read more (PubMed: 17154512) »
  • Nam S  et al. Action of the Src family kinase inhibitor, dasatinib (BMS-354825), on human prostate cancer cells. Cancer Res 65:9185-9 (2005). Read more (PubMed: 16230377) »
  • Lombardo LJ  et al. Discovery of N-(2-chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4- ylamino)thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays. J Med Chem 47:6658-61 (2004). Read more (PubMed: 15615512) »

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