Overview

  • Product name

    DAU 5884 hydrochloride, M3 receptor antagonist
  • Description

    Competitive, potent and selective M3 receptor antagonist
  • Alternative names

    • DAU5884 hydrochloride
  • Biological description

    Competitive, potent and selective M3 receptor antagonist (IC50 values are 8 - 131 nM against 0.3 nM [3H]NMS). Inhibits muscle contractility and shows antiproliferative effects. Centrally active. Active in vivo.

  • Purity

    > 99%
  • CAS Number

    131780-48-8
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    1,4-Dihydro-2-oxo-3(2H)-quinazolinecarboxylic acid (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester hydrochloride
  • Molecular weight

    351.83
  • Molecular formula

    C17H21N3O3.HCl
  • PubChem identifier

    16759154
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    Cl.CN4[C@H]1CC[C@@H]4CC(C1)OC(=O)N2Cc3ccccc3NC2=O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Rinaldo L & Hansel C Muscarinic acetylcholine receptor activation blocks long-term potentiation at cerebellar parallel fiber-Purkinje cell synapses via cannabinoid signaling. Proc Natl Acad Sci U S A 110:11181-6 (2013). Read more (PubMed: 23776234) »
  • Grilli M  et al. Specific inhibitory effect of amyloid-beta on presynaptic muscarinic receptor subtypes modulating neurotransmitter release in the rat nucleus accumbens. Neuroscience 167:482-9 (2010). Read more (PubMed: 20144691) »
  • D'Agostino G  et al. Isolated porcine bronchi provide a reliable model for development of bronchodilator anti-muscarinic agents for human use. Br J Pharmacol 154:1611-8 (2008). Read more (PubMed: 18516071) »

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