Daunorubicin hydrochloride, Anthracycline antibiotic (ab141394)
- Datasheet
- References
Overview
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Product name
Daunorubicin hydrochloride, Anthracycline antibiotic -
Description
Anthracycline antibiotic. DNA and RNA synthesis inhibitor. -
Biological description
Anthracycline antibiotic. DNA and RNA synthesis inhibitor. Reduces tau mRNA levels. Induces DNA fragmentation and apoptosis. Antiproliferative and cytotoxic effects in vivo. Orally active. -
Purity
> 95% -
CAS Number
23541-50-6 -
Chemical structure
Properties
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Chemical name
(7S,9S)-9-Acetyl-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione hydrochloride -
Molecular weight
563.98 -
Molecular formula
C27H29NO10.HCl -
PubChem identifier
62770 -
Storage instructions
Store at +4°C. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 50 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC1C(C(CC(O1)OC2CC(CC3=C(C4=C(C(=C23)O)C(=O)C5=C(C4=O)C=CC=C5OC)O)(C(=O)C)O)N)O.Cl -
Source
Synthetic
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Research areas
References
This product has been referenced in:
- Liu J et al. A modified double-emulsion method for the preparation of daunorubicin-loaded polymeric nanoparticle with enhanced in vitro anti-tumor activity. Biomed Mater 5:065002 (2010). Read more (PubMed: 20924138) »
- Gewirtz DA A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin. Biochem Pharmacol 57:727-41 (1999). Read more (PubMed: 10075079) »
- Boland MP et al. Daunorubicin activates NFkappaB and induces kappaB-dependent gene expression in HL-60 promyelocytic and Jurkat T lymphoma cells. J Biol Chem 272:12952-60 (1997). Read more (PubMed: 9148901) »
