Overview

  • Product name

    DBeQ, p97 ATPase inhibitor
  • Description

    Selective, potent, reversible and ATP competitive p97 ATPase inhibitor
  • Alternative names

    • N2,N4-dibenzylquinazoline-2,4-diamine
  • Biological description

    Selective, potent, reversible and ATP-competitive p97 ATPase inhibitor (IC50 = 1.5 μM). Inhibits a number of cellular processes including ER-associated degradation, ubiquitin fusion degradation and autophagosome maturation. Decreases cancer cell growth and induces activation of caspases 3 and 7.
  • Purity

    > 99%
  • CAS Number

    177355-84-9
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    N2,N4-Bis(phenylmethyl)-2,4-quinazolinediamine
  • Molecular weight

    340.42
  • Molecular formula

    C22H20N4
  • PubChem identifier

    676352
  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM and in ethanol to 20 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    c3cccc4nc(NCc1ccccc1)nc(NCc2ccccc2)c34
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Yi P  et al. Sorafenib-mediated targeting of the AAA? ATPase p97/VCP leads to disruption of the secretory pathway, endoplasmic reticulum stress, and hepatocellular cancer cell death. Mol Cancer Ther 11:2610-20 (2012). Read more (PubMed: 23041544) »
  • Chou TF  et al. Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways. Proc Natl Acad Sci U S A 108:4834-9 (2011). Read more (PubMed: 21383145) »
  • Chou TF & Deshaies RJ Development of p97 AAA ATPase inhibitors. Autophagy 7:1091-2 (2011). Read more (PubMed: 21606684) »

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