Key features and details
- Rabbit polyclonal to DCK
- Suitable for: WB, ICC/IF
- Reacts with: Human
- Isotype: IgG
Product nameAnti-DCK antibody
See all DCK primary antibodies
DescriptionRabbit polyclonal to DCK
Tested applicationsSuitable for: WB, ICC/IFmore details
Species reactivityReacts with: Human
Predicted to work with: Mouse, Rat, Cow
Recombinant fragment corresponding to a region within amino acids 1 - 216 of Human DCK.
- 293T, A431, H1299, HeLa, HepG2, MOLT4 or Raji cell lines.
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage bufferpH: 7.00
Preservative: 0.025% Proclin 300
Constituents: PBS, 20% Glycerol
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab96599 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/500 - 1/3000. Predicted molecular weight: 31 kDa.|
|ICC/IF||1/100 - 1/200.|
FunctionRequired for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents.
Sequence similaritiesBelongs to the DCK/DGK family.
modificationsPhosphorylated upon DNA damage, probably by ATM or ATR.
- Information by UniProt
- dCK antibody
- DCK protein antibody
- DCK_HUMAN antibody
ab96599 has been referenced in 5 publications.
- Hu Q et al. dCK negatively regulates the NRF2/ARE axis and ROS production in pancreatic cancer. Cell Prolif 51:e12456 (2018). PubMed: 29701272
- Zhong R et al. Deoxycytidine kinase participates in the regulation of radiation-induced autophagy and apoptosis in breast cancer cells. Int J Oncol 52:1000-1010 (2018). PubMed: 29393406
- Hammam K et al. Dual protein kinase and nucleoside kinase modulators for rationally designed polypharmacology. Nat Commun 8:1420 (2017). PubMed: 29127277
- Kerr M et al. Deoxycytidine kinase expression underpins response to gemcitabine in bladder cancer. Clin Cancer Res 20:5435-45 (2014). WB . PubMed: 25224279
- Frese KK et al. nab-Paclitaxel potentiates gemcitabine activity by reducing cytidine deaminase levels in a mouse model of pancreatic cancer. Cancer Discov 2:260-269 (2012). PubMed: 22585996