Overview

  • Product name

    Anti-DCLK2 antibody
  • Description

    Rabbit polyclonal to DCLK2
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-P, WBmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide corresponding to Human DCLK2 (C terminal).
    Database link: NP_001035350

  • Positive control

    • Rat brain tissue and tissue lysate.
  • General notes

    Previously labelled as DCAMKL2.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at 4°C (stable for up to 12 months).
  • Storage buffer

    Preservative: 0.02% Sodium azide
    Constituent: PBS
  • Concentration information loading...
  • Purity

    Protein A purified
  • Purification notes

    ab106639 is purified by affinity chromatography via a peptide column.
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab106639 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 5 µg/ml.
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 84 kDa.

Target

  • Function

    Protein kinase with a significantly reduced Ca2+/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm.
  • Sequence similarities

    Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
    Contains 2 doublecortin domains.
    Contains 1 protein kinase domain.
  • Domain

    The doublecortin domains are involved in the colocalization with microtubules.
  • Cellular localization

    Cytoplasm > cytoskeleton. Colocalizes with microtubules.
  • Information by UniProt
  • Database links

  • Alternative names

    • CaMK-like CREB regulatory kinase 2 antibody
    • CL2 antibody
    • CLICK-II antibody
    • CLICK2 antibody
    • DCAMK L2 antibody
    • DCAMKL 2 antibody
    • DCAMKL2 antibody
    • DCDC 3 antibody
    • DCDC 3B antibody
    • DCDC3 antibody
    • DCDC3B antibody
    • DCK 2 antibody
    • DCK2 antibody
    • DCLK 2 antibody
    • Dclk2 antibody
    • DCLK2_HUMAN antibody
    • DKFZp761I032 antibody
    • Doublecortin and CaM kinase like 2 antibody
    • Doublecortin domain-containing protein 3B antibody
    • Doublecortin like and CAM kinase like 2 antibody
    • Doublecortin like kinase 2 antibody
    • Doublecortin-like and CAM kinase-like 2 antibody
    • Doublecortin-like kinase 2 antibody
    • MGC45428 antibody
    • Serine/threonine protein kinase DCLK2 antibody
    • Serine/threonine-protein kinase DCLK2 antibody
    see all

Images

  • Western Blot of rat brain tissue lysate labeling DCLK2 with Anti-DCLK2 antibody (ab106639) at (1) 1 and (2) 2μg/ml.

  • Lane 1 : Anti-DCLK2 antibody (ab106639) at 1 µg/ml
    Lane 2 : Anti-DCLK2 antibody (ab106639) at 2 µg/ml

    All lanes : Rat brain tissue lysate

    Lysates/proteins at 15 µg per lane.

    Predicted band size: 84 kDa

  • ab106639 at 5µg/ml, staining DCLK2 in Rat brain, using Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue.

References

This product has been referenced in:

  • Lipka J  et al. Microtubule-binding protein doublecortin-like kinase 1 (DCLK1) guides kinesin-3-mediated cargo transport to dendrites. EMBO J 35:302-18 (2016). Read more (PubMed: 26758546) »
See 1 Publication for this product

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