Overview

  • Product name

  • Description

    Rabbit polyclonal to Dcp2/TDT
  • Host species

    Rabbit
  • Specificity

    Multiple isoforms of Dcp2/TDT are known to exist.

  • Tested applications

    Suitable for: WB, ICC/IFmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide corresponding to Human Dcp2/TDT (C terminal).
    Database link: NP_689837

  • Positive control

    • 293 cell lysate.
  • General notes

     This product was previously labelled as Dcp2

     

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at -20°C or -80°C. Avoid freeze / thaw cycle. Store undiluted.
  • Storage buffer

    Preservative: 0.02% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab139718 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 48 kDa.
ICC/IF Use a concentration of 20 µg/ml.

Target

  • Function

    Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Plays a role in replication-dependent histone mRNA degradation. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Has higher activity towards mRNAs that lack a poly(A) tail. Has no activity towards a cap structure lacking a RNA moiety.
  • Sequence similarities

    Belongs to the Nudix hydrolase family. DCP2 subfamily.
    Contains 1 nudix hydrolase domain.
  • Post-translational
    modifications

    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localization

    Cytoplasm > P-body. Nucleus. Predominantly cytoplasmic, in processing bodies (PB). A minor amount is nuclear.
  • Information by UniProt
  • Database links

  • Alternative names

    • DCP2 antibody
    • DCP2 decapping enzyme homolog (S. cerevisiae) antibody
    • DCP2, S. cerevisiae, homolog of antibody
    • DCP2_HUMAN antibody
    • decapping enzyme 2, S. cerevisiae, homolog of antibody
    • decapping enzyme homolog (S. cerevisiae) antibody
    • FLJ33245 antibody
    • hDpc antibody
    • m7GpppN-mRNA hydrolase antibody
    • mRNA decapping enzyme 2 antibody
    • mRNA-decapping enzyme 2 antibody
    • Nucleoside diphosphate-linked moiety X motif 20 antibody
    • nudix (nucleoside diphosphate linked moiety X)-type motif 20 antibody
    • Nudix motif 20 antibody
    • NUDT20 antibody
    see all

Images

  • Immunofluorescence of Dcp2/TDT in Human testis tissue with ab139718 at 20 ug/mL.

  • All lanes : Anti-Dcp2/TDT antibody (ab139718) at 1 µg/ml

    Lane 1 : 293 cell lysate
    Lane 2 : 293 cell lysate with blocking peptide

    Lysates/proteins at 15 µg per lane.

    Predicted band size: 48 kDa

References

ab139718 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab139718.
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