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Epigenetics and Nuclear Signaling Chromatin Binding Proteins DNA / RNA binding
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Anti-Dcp2/TDT antibody - C-terminal (ab189966)

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Dcp2/TDT antibody - C-terminal (ab189966)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Dcp2/TDT antibody - C-terminal (ab189966)
  • Western blot - Anti-Dcp2/TDT antibody - C-terminal (ab189966)

Key features and details

  • Rabbit polyclonal to Dcp2/TDT - C-terminal
  • Suitable for: WB, IHC-P
  • Reacts with: Human
  • Isotype: IgG

You may also be interested in

Protein
Product image
Recombinant Human Dcp2/TDT protein (ab132368)
Secondary
Product image
Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

View more associated products

Overview

  • Product name

    Anti-Dcp2/TDT antibody - C-terminal
    See all Dcp2/TDT primary antibodies
  • Description

    Rabbit polyclonal to Dcp2/TDT - C-terminal
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human Dcp2/TDT (C terminal). The exact sequence is proprietary. The peptide corresponds to 18 amino acids.
    Database link: Q8IU60

  • Positive control

    • Small intestine and testis tissue. 293 cell lysate
  • General notes

     This product was previously labelled as Dcp2

     

    Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

    Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

    We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.

    In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

    We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

    Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

    Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    Preservative: 0.02% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

    • Epigenetics and Nuclear Signaling
    • Chromatin Binding Proteins
    • DNA / RNA binding

Associated products

  • Compatible Secondaries

    • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
    • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
  • Isotype control

    • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)
  • Recombinant Protein

    • Recombinant Human Dcp2/TDT protein (ab132368)

Applications

Our Abpromise guarantee covers the use of ab189966 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 48 kDa.
IHC-P Use a concentration of 5 - 20 µg/ml.

Target

  • Function

    Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Plays a role in replication-dependent histone mRNA degradation. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Has higher activity towards mRNAs that lack a poly(A) tail. Has no activity towards a cap structure lacking a RNA moiety.
  • Sequence similarities

    Belongs to the Nudix hydrolase family. DCP2 subfamily.
    Contains 1 nudix hydrolase domain.
  • Post-translational
    modifications

    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localization

    Cytoplasm > P-body. Nucleus. Predominantly cytoplasmic, in processing bodies (PB). A minor amount is nuclear.
  • Target information above from: UniProt accession Q8IU60 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links

    • Entrez Gene: 167227 Human
    • Omim: 609844 Human
    • SwissProt: Q8IU60 Human
    • Unigene: 443875 Human
    • Alternative names

      • DCP2 antibody
      • DCP2 decapping enzyme homolog (S. cerevisiae) antibody
      • DCP2, S. cerevisiae, homolog of antibody
      • DCP2_HUMAN antibody
      • decapping enzyme 2, S. cerevisiae, homolog of antibody
      • decapping enzyme homolog (S. cerevisiae) antibody
      • FLJ33245 antibody
      • hDpc antibody
      • m7GpppN-mRNA hydrolase antibody
      • mRNA decapping enzyme 2 antibody
      • mRNA-decapping enzyme 2 antibody
      • Nucleoside diphosphate-linked moiety X motif 20 antibody
      • nudix (nucleoside diphosphate linked moiety X)-type motif 20 antibody
      • Nudix motif 20 antibody
      • NUDT20 antibody
      see all

    Images

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Dcp2/TDT antibody - C-terminal (ab189966)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Dcp2/TDT antibody - C-terminal (ab189966)

      Immunohistochemistry of formalin-fixed, paraffin-embedded Human small intestine tissue labeling Dcp2/TDT with ab189966 at 10 µg/ml.

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Dcp2/TDT antibody - C-terminal (ab189966)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Dcp2/TDT antibody - C-terminal (ab189966)

      Immunohistochemistry of Human testis tissue labeling Dcp2/TDT with ab189966 at 20 µg/ml. Detection by immunofluorescence.

    • Western blot - Anti-Dcp2/TDT antibody - C-terminal (ab189966)
      Western blot - Anti-Dcp2/TDT antibody - C-terminal (ab189966)
      All lanes : Anti-Dcp2/TDT antibody - C-terminal (ab189966) at 1 µg/ml

      Lane 1 : 293 cell lysate
      Lane 2 : 293 cell lysate with Blocking peptide

      Predicted band size: 48 kDa

    Protocols

    • Western blot protocols
    • Immunohistochemistry protocols

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet
  • References (0)

    Publishing research using ab189966? Please let us know so that we can cite the reference in this datasheet.

    ab189966 has not yet been referenced specifically in any publications.

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