Recombinant fragment corresponding to Human DcR1 aa 30-230. Sequence:
ARQEEVPQQTVAPQQQRHSFKGEECPAGSHRSEHTGACNPCTEGVDYTNA SNNEPSCFPCTVCKSDQKHKSSCTMTRDTVCQCKEGTFRNENSPEMCRKC SRCPSGEVQVSNCTSWDDIQCVEEFGANATVETPAAEETMNTSPGTPAPA AEETMNTSPGTPAPAAEETMTTSPGTPAPAAEETMTTSPGTPAPAAEETM IT
ab171870 - Rabbit polyclonal IgG, is suitable for use as an isotype control with this antibody.
DcR1 / TRAIL-R3 / TRID / LIT is one of the two putative decoy receptors identified for TRAIL, one of the members of TNF family of apoptosis inducing proteins. The other putative decoy receptor is called DcR2 / TRUNDD / TRAIL-R4. DcR1 is attached to the cell surface through glycophospholipid anchor. It has the extracellular TRAIL binding domain but lacks the cytoplasmic domain to induce apoptotic signal. Hence overexpression of DcR1 inhibits the TRAIL induced apoptosis.