Overview

  • Product name

  • Description

    Rabbit polyclonal to DcR1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, Flow Cytmore details
  • Species reactivity

    Reacts with: Rat, Human
  • Immunogen

    Synthetic peptide corresponding to Human DcR1 aa 24-35.
    Sequence:

    YSATTARQEEVP


    (Peptide available as ab5849)

  • Positive control

    • HEK293 Cell Lysate.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer

    Preservative: 0.05% Sodium azide
    Constituents: 0.1% BSA, 99% PBS
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Primary antibody notes

    Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including tumor necrosis factor (TNF) and Fas ligand in the TNF family through their death domain containing receptors, TNF receptor 1 (TNFR1) and Fas, respectively. Another member in the TNF family has been identified and designated TRAIL (for TNF-related apoptosis inducing ligand) and Apo-2L (for Apo-2 ligand). Receptors for TRAIL include two death domain containing receptors, DR4 and DR5, as well as two decoy receptors, DcR1 and DcR2, lacking the intracellular signaling death domain. DcR1 (also called TRID), like the related death receptors DR4 and DR5, contains two extracellular cysteine rich domains. However, DcR1 contains no intracellular death domain and is thus incapable of signaling apoptosis. It has been suggested DcR1 is responsible for TRAIL resistance in normal human tissues including heart, placenta, lung, liver, kidney, spleen, and bone marrow.
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab5808 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Detects a band of approximately 30 kDa (predicted molecular weight: 31 kDa).
Flow Cyt Use at an assay dependent concentration.

ab171870 - Rabbit polyclonal IgG, is suitable for use as an isotype control with this antibody.

 

Target

  • Relevance

    DcR1 / TRAIL-R3 / TRID / LIT is one of the two putative decoy receptors identified for TRAIL, one of the members of TNF family of apoptosis inducing proteins. The other putative decoy receptor is called DcR2 / TRUNDD / TRAIL-R4. DcR1 is attached to the cell surface through glycophospholipid anchor. It has the extracellular TRAIL binding domain but lacks the cytoplasmic domain to induce apoptotic signal. Hence overexpression of DcR1 inhibits the TRAIL induced apoptosis.
  • Cellular localization

    Cell Membrane and Cytoplasmic
  • Database links

  • Alternative names

    • Antagonist decoy receptor for TRAIL/Apo 2L antibody
    • CD263 antibody
    • Cytotoxic TRAIL receptor 3 antibody
    • DCR1 antibody
    • DCR1 TNFR antibody
    • Decoy Receptor 1 antibody
    • Decoy TRAIL receptor without death domain antibody
    • LIT antibody
    • Lymphocyte inhibitor of TRAIL antibody
    • MGC149501 antibody
    • MGC149502 antibody
    • TNF related apoptosis inducing ligand receptor 3 antibody
    • TNF-re ated apoptosis inducing ligand receptor 3 antibody
    • TNFRSF10C antibody
    • TRAIL R3 antibody
    • TRAIL receptor 3 antibody
    • TRAILR3 antibody
    • TRID antibody
    • Tumor necrosis factor receptor superfamily member 10C antibody
    • Tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain antibody
    see all

References

ab5808 has not yet been referenced specifically in any publications.

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