Anti-DcR3 antibody (ab8405)
Key features and details
- Rabbit polyclonal to DcR3
- Suitable for: IHC-P, WB
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-DcR3 antibody
See all DcR3 primary antibodies -
Description
Rabbit polyclonal to DcR3 -
Host species
Rabbit -
Tested applications
Suitable for: IHC-P, WBmore details -
Species reactivity
Reacts with: Human -
Immunogen
Synthetic peptide corresponding to Human DcR3 aa 31-46. Peptide corresponding to amino acids 31 to 46 of human DcR3 precursor (1,2).
(Peptide available asab8437) -
Positive control
- WB: Human heart, brain, and kidney tissue lysates. IHC-P: Human heart tissue.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituent: PBS -
Concentration information loading...
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Purity
Ion Exchange Chromatography -
Clonality
Polyclonal -
Isotype
IgG -
Light chain type
unknown -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab8405 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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IHC-P |
Use a concentration of 1 µg/ml.
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WB |
Use a concentration of 0.5 µg/ml. Detects a band of approximately 33 kDa.
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Notes |
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IHC-P
Use a concentration of 1 µg/ml. |
WB
Use a concentration of 0.5 µg/ml. Detects a band of approximately 33 kDa. |
Target
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Function
Decoy receptor for the cytotoxic ligands TNFS14/LIGHT and TNFSF6/FASL. Protects against apoptosis. -
Tissue specificity
Detected in fetal lung, brain and liver. Detected in adult stomach, spinal cord, lymph node, trachea, spleen, colon and lung. Highly expressed in several primary tumors from colon, stomach, rectum, esophagus and in SW480 colon carcinoma cells. -
Sequence similarities
Contains 4 TNFR-Cys repeats. -
Cellular localization
Secreted. - Information by UniProt
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Database links
- Entrez Gene: 8771 Human
- Omim: 603361 Human
- SwissProt: O95407 Human
- Unigene: 434878 Human
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Alternative names
- DcR3 antibody
- Decoy receptor 3 antibody
- Decoy receptor for Fas ligand antibody
see all
Images
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All lanes : Anti-DcR3 antibody (ab8405) at 1/500 dilution
Lane 1 : Human heart tissue lysate
Lane 2 : Human brain tissue lysate
Lane 3 : Human kidney tissue lysate
Observed band size: 33 kDa why is the actual band size different from the predicted? -
ab8405 at 1µg/ml staining DcR3 in human heart tissue by IHC.
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (2)
ab8405 has been referenced in 2 publications.
- Chen X et al. Decoy receptor-3 regulates inflammation and apoptosis via PI3K/AKT signaling pathway in coronary heart disease. Exp Ther Med 17:2614-2622 (2019). PubMed: 30906453
- Yu W et al. DcR3 regulates the growth and metastatic potential of SW480 colon cancer cells. Oncol Rep 30:2741-8 (2013). PubMed: 24101127