• Product name
  • Description
    Rabbit polyclonal to DCTN1
  • Host species
  • Tested applications
    Suitable for: WB, IHC-P, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide containing a sequence corresponding to a region within amino acids 1216 and 1248 of Human DCTN1 (NP_004073).

  • Positive control
    • Jurkat whole cell lysates for WB. HeLa cells for IF. OV CA for IHC-P.



Our Abpromise guarantee covers the use of ab96004 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 142 kDa.
IHC-P 1/100 - 1/500.
ICC/IF 1/100 - 1/200.


  • Function
    Required for the cytoplasmic dynein-driven retrograde movement of vesicles and organelles along microtubules. Dynein-dynactin interaction is a key component of the mechanism of axonal transport of vesicles and organelles.
  • Tissue specificity
  • Involvement in disease
    Defects in DCTN1 are the cause of distal hereditary motor neuronopathy type 7B (HMN7B) [MIM:607641]; also known as progressive lower motor neuron disease (PLMND). HMN7B is a neuromuscular disorder. Distal hereditary motor neuronopathies constitute a heterogeneous group of neuromuscular disorders caused by selective degeneration of motor neurons in the anterior horn of the spinal cord, without sensory deficit in the posterior horn. The overall clinical picture consists of a classical distal muscular atrophy syndrome in the legs without clinical sensory loss. The disease starts with weakness and wasting of distal muscles of the anterior tibial and peroneal compartments of the legs. Later on, weakness and atrophy may expand to the proximal muscles of the lower limbs and/or to the distal upper limbs.
    Defects in DCTN1 are a cause of susceptibility to amyotrophic lateral sclerosis (ALS) [MIM:105400]. ALS is a neurodegenerative disorder affecting upper and lower motor neurons, and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology is likely to be multifactorial, involving both genetic and environmental factors.
    Defects in DCTN1 are the cause of Perry syndrome (PERRYS) [MIM:168605]; also called parkinsonism with alveolar hypoventilation and mental depression. Perry syndrome is a neuropsychiatric disorder characterized by mental depression not responsive to antidepressant drugs or electroconvulsive therapy, sleep disturbances, exhaustion and marked weight loss. Parkinsonism develops later and respiratory failure occurred terminally.
  • Sequence similarities
    Belongs to the dynactin 150 kDa subunit family.
    Contains 1 CAP-Gly domain.
  • Post-translational
    Ubiquitinated by a SCF complex containing FBXL5, leading to its degradation by the proteasome.
  • Cellular localization
    Cytoplasm. Cytoplasm > cytoskeleton.
  • Information by UniProt
  • Database links
  • Alternative names
    • 150 kDa dynein associated polypeptide antibody
    • 150 kDa dynein-associated polypeptide antibody
    • DAP 150 antibody
    • DAP-150 antibody
    • DAP150 antibody
    • DCTN 1 antibody
    • DCTN1 antibody
    • DCTN1_HUMAN antibody
    • DP 150 antibody
    • DP-150 antibody
    • DP150 antibody
    • Dynactin 1 (p150 Glued (Drosophila) homolog) antibody
    • Dynactin 1 (p150 glued homolog Drosophila) antibody
    • Dynactin 1 antibody
    • Dynactin subunit 1 antibody
    • Dynactin1 antibody
    • HMN7B antibody
    • p135 antibody
    • p150 Glued (Drosophila) homolog antibody
    • p150 glued antibody
    • p150 glued homolog antibody
    • p150(GLUED) DROSOPHILA HOMOLOG OF antibody
    • p150-glued antibody
    • p150glued antibody
    see all


  • Anti-DCTN1 antibody (ab96004) at 1/3000 dilution + Jurkat whole cell lysate at 30 µg

    Predicted band size: 142 kDa

    5% SDS PAGE
  • Immunofluorescence analysis of methanol-fixed HeLa cells, using ab96004 at 1/200 dilution. Lower image costained with Hoerchst 33342.
  • Immunohistochemical analysis of paraffin-embedded OV CA, using ab96004 at 1/100 dilution.


ab96004 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab96004.
Please use the links above to contact us or submit feedback about this product.


Sign up