Overview

  • Product name

    Anti-DCTN1/p150-glued antibody
    See all DCTN1/p150-glued primary antibodies
  • Description

    Rabbit polyclonal to DCTN1/p150-glued
  • Host species

    Rabbit
  • Specificity

    Reacts specifically with 141 kDa DCTN1 / p150-glued protein from Drosophila melanogaster.

  • Tested applications

    Suitable for: IHC-P, IHC-Fr, WBmore details
  • Species reactivity

    Reacts with: Drosophila melanogaster
  • Immunogen

    Synthetic peptide corresponding to Drosophila melanogaster DCTN1/p150-glued (N terminal).

  • General notes

    Previously labelled as DCTN1. 

Properties

Applications

Our Abpromise guarantee covers the use of ab80257 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use at an assay dependent concentration.
IHC-Fr Use at an assay dependent concentration.
WB 1/500 - 1/5000. Predicted molecular weight: 142 kDa.

Target

  • Function

    Required for the cytoplasmic dynein-driven retrograde movement of vesicles and organelles along microtubules. Dynein-dynactin interaction is a key component of the mechanism of axonal transport of vesicles and organelles.
  • Tissue specificity

    Brain.
  • Involvement in disease

    Defects in DCTN1 are the cause of distal hereditary motor neuronopathy type 7B (HMN7B) [MIM:607641]; also known as progressive lower motor neuron disease (PLMND). HMN7B is a neuromuscular disorder. Distal hereditary motor neuronopathies constitute a heterogeneous group of neuromuscular disorders caused by selective degeneration of motor neurons in the anterior horn of the spinal cord, without sensory deficit in the posterior horn. The overall clinical picture consists of a classical distal muscular atrophy syndrome in the legs without clinical sensory loss. The disease starts with weakness and wasting of distal muscles of the anterior tibial and peroneal compartments of the legs. Later on, weakness and atrophy may expand to the proximal muscles of the lower limbs and/or to the distal upper limbs.
    Defects in DCTN1 are a cause of susceptibility to amyotrophic lateral sclerosis (ALS) [MIM:105400]. ALS is a neurodegenerative disorder affecting upper and lower motor neurons, and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology is likely to be multifactorial, involving both genetic and environmental factors.
    Defects in DCTN1 are the cause of Perry syndrome (PERRYS) [MIM:168605]; also called parkinsonism with alveolar hypoventilation and mental depression. Perry syndrome is a neuropsychiatric disorder characterized by mental depression not responsive to antidepressant drugs or electroconvulsive therapy, sleep disturbances, exhaustion and marked weight loss. Parkinsonism develops later and respiratory failure occurred terminally.
  • Sequence similarities

    Belongs to the dynactin 150 kDa subunit family.
    Contains 1 CAP-Gly domain.
  • Post-translational
    modifications

    Ubiquitinated by a SCF complex containing FBXL5, leading to its degradation by the proteasome.
  • Cellular localization

    Cytoplasm. Cytoplasm > cytoskeleton.
  • Information by UniProt
  • Database links

    • Alternative names

      • 150 kDa dynein associated polypeptide antibody
      • 150 kDa dynein-associated polypeptide antibody
      • DAP 150 antibody
      • DAP-150 antibody
      • DAP150 antibody
      • DCTN 1 antibody
      • DCTN1 antibody
      • DCTN1_HUMAN antibody
      • DP 150 antibody
      • DP-150 antibody
      • DP150 antibody
      • Dynactin 1 (p150 Glued (Drosophila) homolog) antibody
      • Dynactin 1 (p150 glued homolog Drosophila) antibody
      • Dynactin 1 antibody
      • Dynactin subunit 1 antibody
      • Dynactin1 antibody
      • HMN7B antibody
      • p135 antibody
      • p150 Glued (Drosophila) homolog antibody
      • p150 glued antibody
      • p150 glued homolog antibody
      • p150(GLUED) DROSOPHILA HOMOLOG OF antibody
      • p150-glued antibody
      • p150glued antibody
      see all

    References

    ab80257 has not yet been referenced specifically in any publications.

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