Overview

  • Product name

    Anti-DCUN1D1 antibody (Biotin)
    See all DCUN1D1 primary antibodies
  • Description

    Goat polyclonal to DCUN1D1 (Biotin)
  • Host species

    Goat
  • Conjugation

    Biotin
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Chicken
  • Immunogen

    Synthetic peptide corresponding to Human DCUN1D1 aa 248-258 (C terminal) (Cysteine residue). (NP_065691.2)
    Sequence:

    C-RPQIAGTKSTT


    Database link: Q96GG9

  • Positive control

    • WB: HepG2 cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab239742 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.3 - 1 µg/ml.

Target

  • Relevance

    DCUN1D1 (DCUN1 domain-containing protein 1) contains a DUF298 domain and a UBA-like ubiquitin. Forms part of an E3 ubiquitin ligase complex for neddylation. Required for neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes by enhancing the rate of cullins neddylation. Functions to recruit the NEDD8-charged E2 enzyme to the cullin component. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity. Acts also as an oncogene facilitating malignant transformation and carcinogenic progression. Defects in DCUN1D1 may be a cause of squamous cell carcinomas. Strongly overexpressed in thyroid tumors, bronchioloalveolar carcinomas, and malignant tissues of squamous cell carcinoma of the oral tongue. Not overexpressed in aggressive adrenocortical carcinomas.
  • Database links

  • Alternative names

    • DCN1 defective in cullin neddylation 1 domain containing 1 antibody
    • DCN1 like protein 1 antibody
    • DCNL1 antibody
    • DCUN1 domain containing protein 1 antibody
    • DCUN1L1 antibody
    • Defective in cullin neddylation protein 1 like protein 1 antibody
    • RP 42 antibody
    • RP42 antibody
    • RP42 homolog antibody
    • SCCRO antibody
    • SCRO antibody
    • Squamous cell carcinoma related oncogene antibody
    • Tes 3 antibody
    • Tes3 antibody
    see all

Images

  • Anti-DCUN1D1 antibody (Biotin) (ab239742) at 0.5 µg/ml + HepG2 (human liver hepatocellular carcinoma cell line) cell lysate (in RIPA buffer) at 35 µg


    Primary incubation for 1 hour. Detected by chemiluminescence, using streptavidin-HRP and using NAP blocker as a substitute for skimmed milk.

References

ab239742 has not yet been referenced specifically in any publications.

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