Overview

  • Product name

  • Description

    Goat polyclonal to DCXR
  • Host species

    Goat
  • Tested applications

    Suitable for: IHC-P, ELISA, WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Guinea pig, Hamster
  • Immunogen

    Synthetic peptide:

    GSTLPVEGGFWAC

    , corresponding to amino acids 232-244 of Human DCXR.

  • Positive control

    • Recombinant Human DCXR protein (ab117694) can be used as a positive control in WB. Hela and Human Kidney lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab11800 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P
ELISA
WB
  • Application notes
    ELISA: 1/32000.
    WB: Use at a concentration of 0.1 - 0.5 µg/ml. Detects a band of approximately 28 kDa in Hela and Human Kidney lysates.
    IHC-P: Use at a concentration of 1 - 2 µg/ml. In paraffin embedded Human Kidney, stains membrane / cytoplasm in epithelial cells of renal glomeruli and tubules.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function

      Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules.
    • Tissue specificity

      Highly expressed in kidney, liver and epididymis. In the epididymis, it is mainly expressed in the proximal and distal sections of the corpus region. Weakly or not expressed in brain, lung, heart, spleen and testis.
    • Involvement in disease

      Note=The enzyme defect in pentosuria has been shown to involve L-xylulose reductase. Essential pentosuria is an inborn error of metabolism characterized by the excessive urinary excretion of the pentose L-xylulose.
    • Sequence similarities

      Belongs to the short-chain dehydrogenases/reductases (SDR) family.
    • Cellular localization

      Membrane. Probably recruited to membranes via an interaction with phosphatidylinositol.
    • Information by UniProt
    • Database links

    • Alternative names

      • Carbonyl reductase 2 antibody
      • Carbonyl reductase II antibody
      • DCR antibody
      • Dcxr antibody
      • DCXR_HUMAN antibody
      • Dicarbonyl and L xylulose reductase antibody
      • Dicarbonyl L xylulose reductase antibody
      • Dicarbonyl/ L xylulose reductase antibody
      • Dicarbonyl/L-xylulose reductase antibody
      • HCR2 antibody
      • HCRII antibody
      • Human carbonyl reductase 2 antibody
      • kiDCR antibody
      • Kidney dicarbonyl reductase antibody
      • L xylulose reductase antibody
      • L-xylulose reductase antibody
      • P34H antibody
      • PNTSU antibody
      • SDR20C1 antibody
      • Short chain dehydrogenase/reductase family 20C member 1 antibody
      • Sperm surface protein P34H antibody
      • XR antibody
      see all

    Images

    • Ab11800 staining (0.1µg/ml) of Human Kidney lysate (RIPA buffer, 35µg total protein per lane).  Primary incubated for 1 hour.  Detected by western blot using chemiluminescence. Ab11800 staining (0.1µg/ml) of Human Kidney lysate (RIPA buffer, 35µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
    • Ab11800 (1ug/ml) staining human DCXR in human kidney by immunohistochemistry using paraffin embedded tissue.

      Microwaved antigen retrieval with citrate buffer, pH6, HRP-staining.

    References

    ab11800 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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