Overview

  • Product name
    Anti-DCXR antibody
    See all DCXR primary antibodies
  • Description
    Rabbit polyclonal to DCXR
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 1-244 of Human DCXR (UniProt: Q7Z4W1).

  • Positive control
    • HepG2 whole cell lysate; Human H661 xenograft tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab154290 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 26 kDa.
IHC-P 1/100 - 1/1000. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function
    Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules.
  • Tissue specificity
    Highly expressed in kidney, liver and epididymis. In the epididymis, it is mainly expressed in the proximal and distal sections of the corpus region. Weakly or not expressed in brain, lung, heart, spleen and testis.
  • Involvement in disease
    Note=The enzyme defect in pentosuria has been shown to involve L-xylulose reductase. Essential pentosuria is an inborn error of metabolism characterized by the excessive urinary excretion of the pentose L-xylulose.
  • Sequence similarities
    Belongs to the short-chain dehydrogenases/reductases (SDR) family.
  • Cellular localization
    Membrane. Probably recruited to membranes via an interaction with phosphatidylinositol.
  • Information by UniProt
  • Database links
    see all
  • Alternative names
    • Carbonyl reductase 2 antibody
    • Carbonyl reductase II antibody
    • DCR antibody
    • Dcxr antibody
    • DCXR_HUMAN antibody
    • Dicarbonyl and L xylulose reductase antibody
    • Dicarbonyl L xylulose reductase antibody
    • Dicarbonyl/ L xylulose reductase antibody
    • Dicarbonyl/L-xylulose reductase antibody
    • HCR2 antibody
    • HCRII antibody
    • Human carbonyl reductase 2 antibody
    • kiDCR antibody
    • Kidney dicarbonyl reductase antibody
    • L xylulose reductase antibody
    • L-xylulose reductase antibody
    • P34H antibody
    • PNTSU antibody
    • SDR20C1 antibody
    • Short chain dehydrogenase/reductase family 20C member 1 antibody
    • Sperm surface protein P34H antibody
    • XR antibody
    see all

Images

  • Western blot - Anti-DCXR antibody (ab154290)
    Western blot - Anti-DCXR antibody (ab154290)
    Anti-DCXR antibody (ab154290) at 1/1000 dilution + HepG2 whole cell
    lysate at 30 µg

    Predicted band size: 26 kDa



    12% SDS PAGE
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DCXR antibody (ab154290)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DCXR antibody (ab154290)
    Immunohistochemical analysis of paraffin-embedded Human H661 xenograft tissue labeling DCXR with ab154290 at 1/500 dilution.

References

ab154290 has not yet been referenced specifically in any publications.

Publishing research using ab154290? Please let us know so that we can cite the reference in this datasheet.

Customer reviews and Q&As

Submit a review Submit a question

There are currently no Customer reviews or Questions for ab154290.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up