Anti-DCXR antibody (ab154290)

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Western blot - Anti-DCXR antibody (ab154290)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DCXR antibody (ab154290)

Key features and details

  • Rabbit polyclonal to DCXR
  • Suitable for: WB, IHC-P
  • Reacts with: Human
  • Isotype: IgG

Overview

  • Product name

    Anti-DCXR antibody
    See all DCXR primary antibodies

  • Description

    Rabbit polyclonal to DCXR

  • Host species

    Rabbit

  • Tested applications

    Suitable for: WB, IHC-Pmore details

  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow

  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 1-244 of Human DCXR (UniProt: Q7Z4W1).

  • Positive control

    • HepG2 whole cell lysate; Human H661 xenograft tissue.

  • General notes

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

    If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

Properties

Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab154290 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
1/500 - 1/3000. Predicted molecular weight: 26 kDa.
IHC-P
1/100 - 1/1000. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
Notes
WB
1/500 - 1/3000. Predicted molecular weight: 26 kDa.
IHC-P
1/100 - 1/1000. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function

    Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules.

  • Tissue specificity

    Highly expressed in kidney, liver and epididymis. In the epididymis, it is mainly expressed in the proximal and distal sections of the corpus region. Weakly or not expressed in brain, lung, heart, spleen and testis.

  • Involvement in disease

    Note=The enzyme defect in pentosuria has been shown to involve L-xylulose reductase. Essential pentosuria is an inborn error of metabolism characterized by the excessive urinary excretion of the pentose L-xylulose.

  • Sequence similarities

    Belongs to the short-chain dehydrogenases/reductases (SDR) family.

  • Cellular localization

    Membrane. Probably recruited to membranes via an interaction with phosphatidylinositol.
  • Information by UniProt

  • Database links

    see all

  • Alternative names

    • Carbonyl reductase 2 antibody
    • Carbonyl reductase II antibody
    • DCR antibody
    • Dcxr antibody
    • DCXR_HUMAN antibody
    • Dicarbonyl and L xylulose reductase antibody
    • Dicarbonyl L xylulose reductase antibody
    • Dicarbonyl/ L xylulose reductase antibody
    • Dicarbonyl/L-xylulose reductase antibody
    • HCR2 antibody
    • HCRII antibody
    • Human carbonyl reductase 2 antibody
    • kiDCR antibody
    • Kidney dicarbonyl reductase antibody
    • L xylulose reductase antibody
    • L-xylulose reductase antibody
    • P34H antibody
    • PNTSU antibody
    • SDR20C1 antibody
    • Short chain dehydrogenase/reductase family 20C member 1 antibody
    • Sperm surface protein P34H antibody
    • XR antibody
    see all

Images

  • Western blot - Anti-DCXR antibody (ab154290)
    Western blot - Anti-DCXR antibody (ab154290)
    Anti-DCXR antibody (ab154290) at 1/1000 dilution + HepG2 whole cell
    lysate at 30 µg

    Predicted band size: 26 kDa



    12% SDS PAGE
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DCXR antibody (ab154290)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DCXR antibody (ab154290)
    Immunohistochemical analysis of paraffin-embedded Human H661 xenograft tissue labeling DCXR with ab154290 at 1/500 dilution.

References (0)

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ab154290 has not yet been referenced specifically in any publications.

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