Anti-DDIT3 antibody [9C8] (ab11419)

Mouse monoclonal DDIT3 antibody [9C8]. Validated in WB, IP, IHC, ICC/IF and tested in Mouse, Rat, Human. Cited in 86 publication(s). Independently reviewed in 22 review(s).

Publishing research using ab11419? Please let us know so that we can cite the reference in this datasheet.

ab11419 has been referenced in 94 publications.

  • Feng W  et al. GCN2 deficiency ameliorates cardiac dysfunction in diabetic mice by reducing lipotoxicity and oxidative stress. Free Radic Biol Med 130:128-139 (2019). PubMed: 30389499
  • Zhou XT  et al. Inhibition of autophagy enhances adenosine-induced apoptosis in human hepatoblastoma HepG2 cells. Oncol Rep 41:829-838 (2019). PubMed: 30535464
  • Han B  et al. PRSS23 knockdown inhibits gastric tumorigenesis through EIF2 signaling. Pharmacol Res 142:50-57 (2019). PubMed: 30769097
  • Lu T  et al. The mechanism on phosphorylation of Hsp20Ser16 inhibit GA stress and ER stress during OGD/R. PLoS One 14:e0213410 (2019). PubMed: 30845231
  • Cui Y  et al. Protective effect of Barbaloin in a rat model of myocardial ischemia reperfusion injury through the regulation of the CNPY2-PERK pathway. Int J Mol Med 43:2015-2023 (2019). PubMed: 30864682
  • Wang Q  et al. Efficacy of celastrol combined with cisplatin in enhancing the apoptosis of U-2OS osteosarcoma cells via the mitochondrial and endoplasmic reticulum pathways of apoptosis. Oncol Lett 17:3305-3313 (2019). PubMed: 30867764
  • Cao Y  et al. ER stress-induced mediator C/EBP homologous protein thwarts effector T cell activity in tumors through T-bet repression. Nat Commun 10:1280 (2019). PubMed: 30894532
  • Tsalikis J  et al. Isoginkgetin, a Natural Biflavonoid Proteasome Inhibitor, Sensitizes Cancer Cells to Apoptosis via Disruption of Lysosomal Homeostasis and Impaired Protein Clearance. Mol Cell Biol 39:N/A (2019). PubMed: 30910794
  • Xu L  et al. Bcl-2 overexpression reduces cisplatin cytotoxicity by decreasing ER-mitochondrial Ca2+ signaling in SKOV3 cells. Oncol Rep 39:985-992 (2018). PubMed: 29286126
  • Cheng F  et al. Synergistic neuroprotective effects of Geniposide and ursodeoxycholic acid in hypoxia-reoxygenation injury in SH-SY5Y cells. Exp Ther Med 15:320-326 (2018). PubMed: 29375691
  • Sun X  et al. Neuritin Attenuates Neuronal Apoptosis Mediated by Endoplasmic Reticulum Stress In Vitro. Neurochem Res 43:1383-1391 (2018). PubMed: 29790068
  • Loeuillard E  et al. Endoplasmic reticulum stress induces inverse regulations of major functions in portal myofibroblasts during liver fibrosis progression. Biochim Biophys Acta Mol Basis Dis 1864:3688-3696 (2018). PubMed: 30292633
  • Shen J  et al. TRPV4 channels stimulate Ca2+-induced Ca2+ release in mouse neurons and trigger endoplasmic reticulum stress after intracerebral hemorrhage. Brain Res Bull 146:143-152 (2018). PubMed: 30508606
  • Wang MG  et al. Activation of PERK-eIF2a-ATF4-CHOP axis triggered by excessive ER stress contributes to lead-induced nephrotoxicity. Biochim Biophys Acta Mol Cell Res N/A:N/A (2018). PubMed: 30528975
  • Leipnitz G  et al. Evaluation of mitochondrial bioenergetics, dynamics, endoplasmic reticulum-mitochondria crosstalk, and reactive oxygen species in fibroblasts from patients with complex I deficiency. Sci Rep 8:1165 (2018). WB ; Human . PubMed: 29348607
  • Xie Q  et al. TAT-fused IP3R-derived peptide enhances cisplatin sensitivity of ovarian cancer cells by increasing ER Ca2+ release. Int J Mol Med 41:809-817 (2018). PubMed: 29207009
  • Garner KL  et al. Enhanced insulin receptor, but not PI3K, signalling protects podocytes from ER stress. Sci Rep 8:3902 (2018). PubMed: 29500363
  • Li PC  et al. Seawater inhalation induces acute lung injury via ROS generation and the endoplasmic reticulum stress pathway. Int J Mol Med 41:2505-2516 (2018). PubMed: 29436612
  • Meng C  et al. PERK Pathway Activation Promotes Intracerebral Hemorrhage Induced Secondary Brain Injury by Inducing Neuronal Apoptosis Both in Vivo and in Vitro. Front Neurosci 12:111 (2018). PubMed: 29541018
  • Lee YL  et al. Epigallocatechin-3-gallate alleviates bladder overactivity in a rat model with metabolic syndrome and ovarian hormone deficiency through mitochondria apoptosis pathways. Sci Rep 8:5358 (2018). PubMed: 29599473
  • Hansson SF  et al. Secretagogin is increased in plasma from type 2 diabetes patients and potentially reflects stress and islet dysfunction. PLoS One 13:e0196601 (2018). PubMed: 29702679
  • Wang Y  et al. GCN2 deficiency ameliorates doxorubicin-induced cardiotoxicity by decreasing cardiomyocyte apoptosis and myocardial oxidative stress. Redox Biol 17:25-34 (2018). PubMed: 29660505
  • Liu J  et al. IRAK2 counterbalances oncogenic Smurf1 in colon cancer cells by dictating ER stress. Cell Signal 48:69-80 (2018). PubMed: 29753111
  • Lei X  et al. Diazoxide inhibits of ER stress-mediated apoptosis during oxygen-glucose deprivation in vitro and cerebral ischemia-reperfusion in vivo. Mol Med Rep 17:8039-8046 (2018). PubMed: 29693708
  • Wei X  et al. GMDS knockdown impairs cell proliferation and survival in human lung adenocarcinoma. BMC Cancer 18:600 (2018). PubMed: 29843634
  • Shu Q  et al. Protective effects of Progranulin against focal cerebral ischemia-reperfusion injury in rats by suppressing endoplasmic reticulum stress and NF-?B activation in reactive astrocytes. J Cell Biochem 119:6584-6597 (2018). PubMed: 29665049
  • Liu S  et al. GCN2 deficiency protects against high fat diet induced hepatic steatosis and insulin resistance in mice. Biochim Biophys Acta Mol Basis Dis N/A:N/A (2018). PubMed: 30006154
  • Martinotti S  et al. (-)- Epigallocatechin-3-gallate induces GRP78 accumulation in the ER and shifts mesothelioma constitutive UPR into proapoptotic ER stress. J Cell Physiol 233:7082-7090 (2018). PubMed: 29744892
  • Xu W  et al. Apelin-13 Alleviates Early Brain Injury after Subarachnoid Hemorrhage via Suppression of Endoplasmic Reticulum Stress-mediated Apoptosis and Blood-Brain Barrier Disruption: Possible Involvement of ATF6/CHOP Pathway. Neuroscience 388:284-296 (2018). PubMed: 30036660
  • Du L  et al. eNOS/iNOS and endoplasmic reticulum stress-induced apoptosis in the placentas of patients with preeclampsia. J Hum Hypertens 31:49-55 (2017). PubMed: 27030287
  • Hu HJ  et al. Protective effects of hydrogen sulfide against angiotensin II-induced endoplasmic reticulum stress in HUVECs. Mol Med Rep 15:2213-2222 (2017). PubMed: 28259956
  • Hammad AS  et al. Structure-activity relationship of piperine and its synthetic amide analogs for therapeutic potential to prevent experimentally induced ER stress in vitro. Cell Stress Chaperones 22:417-428 (2017). PubMed: 28397086
  • Oteng AB  et al. Feeding Angptl4-/- mice trans fat promotes foam cell formation in mesenteric lymph nodes without leading to ascites. J Lipid Res 58:1100-1113 (2017). PubMed: 28412693
  • Wang G  et al. The novel autophagy inhibitor elaiophylin exerts antitumor activity against multiple myeloma with mutant TP53 in part through endoplasmic reticulum stress-induced apoptosis. Cancer Biol Ther 18:584-595 (2017). PubMed: 28718729
  • Stewart C  et al. Regulation of IRE1a by the small molecule inhibitor 4µ8c in hepatoma cells. Endoplasmic Reticulum Stress Dis 4:1-10 (2017). PubMed: 29098149
  • López I  et al. p53-mediated suppression of BiP triggers BIK-induced apoptosis during prolonged endoplasmic reticulum stress. Cell Death Differ 24:1717-1729 (2017). WB . PubMed: 28622297
  • Takahashi N  et al. Activation of Endoplasmic Reticulum Stress in Granulosa Cells from Patients with Polycystic Ovary Syndrome Contributes to Ovarian Fibrosis. Sci Rep 7:10824 (2017). IHC-P ; Mouse, Human . PubMed: 28883502
  • Gan L  et al. Reduced Endoplasmic Reticulum Stress-Mediated Autophagy Is Required for Leptin Alleviating Inflammation in Adipose Tissue. Front Immunol 8:1507 (2017). PubMed: 29250056
  • Wang MG  et al. CaMKII is involved in subcellular Ca2+redistribution-induced endoplasmic reticulum stress leading to apoptosis in primary cultures of rat proximal tubular cells exposed to lead. Oncotarget 8:91162-91173 (2017). PubMed: 29207633
  • Qie X  et al. Endoplasmic Reticulum Stress Mediates Methamphetamine-Induced Blood-Brain Barrier Damage. Front Pharmacol 8:639 (2017). PubMed: 28959203
  • Bu LJ  et al. Melatonin, a novel selective ATF-6 inhibitor, induces human hepatoma cell apoptosis through COX-2 downregulation. World J Gastroenterol 23:986-998 (2017). PubMed: 28246472
  • Liu J  et al. A critical role of DDRGK1 in endoplasmic reticulum homoeostasis via regulation of IRE1a stability. Nat Commun 8:14186 (2017). PubMed: 28128204
  • Wang X  et al. Lyn kinase represses mucus hypersecretion by regulating IL-13-induced endoplasmic reticulum stress in asthma. EBioMedicine 15:137-149 (2017). WB, IHC-P ; Mouse, Human . PubMed: 28024734
  • Wu Z  et al. Silencing of both ATF4 and PERK inhibits cell cycle progression and promotes the apoptosis of differentiating chondrocytes. Int J Mol Med 40:101-111 (2017). WB, IHC ; Mouse . PubMed: 28498443
  • Zhang Z  et al. Homocysteine Induces Apoptosis of Human Umbilical Vein Endothelial Cells via Mitochondrial Dysfunction and Endoplasmic Reticulum Stress. Oxid Med Cell Longev 2017:5736506 (2017). WB ; Human . PubMed: 28630659
  • Li P  et al. Uric acid enhances PKC-dependent eNOS phosphorylation and mediates cellular ER stress: A mechanism for uric acid-induced endothelial dysfunction. Int J Mol Med 37:989-97 (2016). PubMed: 26935704
  • Bao W  et al. Induction of autophagy by the MG-132 proteasome inhibitor is associated with endoplasmic reticulum stress in MCF-7 cells. Mol Med Rep 13:796-804 (2016). PubMed: 26648402
  • Ulbrich L  et al. Autism-associated R451C mutation in neuroligin3 leads to activation of the unfolded protein response in a PC12 Tet-On inducible system. Biochem J 473:423-34 (2016). WB, ICC/IF ; Rat . PubMed: 26621873
  • Sun XY  et al. Valproate attenuates diabetic nephropathy through inhibition of endoplasmic reticulum stress-induced apoptosis. Mol Med Rep 13:661-8 (2016). WB, IHC-P ; Rat . PubMed: 26647757
  • Shen L  et al. Calcium efflux from the endoplasmic reticulum regulates cisplatin-induced apoptosis in human cervical cancer HeLa cells. Oncol Lett 11:2411-2419 (2016). Human . PubMed: 27073489
  • Ding Y  et al. A modifier screen identifies DNAJB6 as a cardiomyopathy susceptibility gene. JCI Insight 1:N/A (2016). WB ; Human . PubMed: 27642634
  • Zhang S  et al. Novel Role of ER Stress and Autophagy in Microcystin-LR Induced Apoptosis in Chinese Hamster Ovary Cells. Front Physiol 7:527 (2016). WB ; Chinese hamster . PubMed: 27877136
  • Zhou X  et al. Propofol Decreases Endoplasmic Reticulum Stress-Mediated Apoptosis in Retinal Pigment Epithelial Cells. PLoS One 11:e0157590 (2016). PubMed: 27311010
  • Xu Y  et al. Myricetin induces apoptosis via endoplasmic reticulum stress and DNA double-strand breaks in human ovarian cancer cells. Mol Med Rep 13:2094-100 (2016). WB . PubMed: 26782830
  • Kong S  et al. Multi-transgenic minipig models exhibiting potential for hepatic insulin resistance and pancreatic apoptosis. Mol Med Rep 13:669-80 (2016). WB . PubMed: 26648014
  • Pang XX  et al. Urotensin II Induces ER Stress and EMT and Increase Extracellular Matrix Production in Renal Tubular Epithelial Cell in Early Diabetic Mice. Kidney Blood Press Res 41:434-49 (2016). PubMed: 27467277
  • Xie Q  et al. ABT737 reverses cisplatin resistance by regulating ER-mitochondria Ca2+ signal transduction in human ovarian cancer cells. Int J Oncol 49:2507-2519 (2016). PubMed: 27748803
  • Christensen DP  et al. Reciprocal signals between microglia and neurons regulate a-synuclein secretion by exophagy through a neuronal cJUN-N-terminal kinase-signaling axis. J Neuroinflammation 13:59 (2016). PubMed: 26957005
  • Zhuang J  et al. Signal transducer and activator of transcription 3 regulates CCAAT-enhancer-binding homologous protein expression in osteoblasts through upregulation of microRNA-205. Exp Ther Med 10:295-299 (2015). PubMed: 26170952
  • Kang JQ  et al. The human epilepsy mutation GABRG2(Q390X) causes chronic subunit accumulation and neurodegeneration. Nat Neurosci 18:988-96 (2015). PubMed: 26005849
  • Kien CL  et al. Lipidomic evidence that lowering the typical dietary palmitate to oleate ratio in humans decreases the leukocyte production of proinflammatory cytokines and muscle expression of redox-sensitive genes. J Nutr Biochem 26:1599-606 (2015). WB . PubMed: 26324406
  • Greenwood M  et al. Transcription Factor CREB3L1 Regulates Endoplasmic Reticulum Stress Response Genes in the Osmotically Challenged Rat Hypothalamus. PLoS One 10:e0124956 (2015). Rat . PubMed: 25915053
  • Varadarajan S  et al. The transrepression arm of glucocorticoid receptor signaling is protective in mutant huntingtin-mediated neurodegeneration. Cell Death Differ 22:1388-96 (2015). PubMed: 25656655
  • Nadeau MÈ  et al. Pharmacological targeting of valosin containing protein (VCP) induces DNA damage and selectively kills canine lymphoma cells. BMC Cancer 15:479 (2015). WB ; Dog . PubMed: 26104798
  • Liu KM  et al. Ketamine-induced ulcerative cystitis and bladder apoptosis involve oxidative stress mediated by mitochondria and the endoplasmic reticulum. Am J Physiol Renal Physiol 309:F318-31 (2015). WB, IF ; Rat . PubMed: 26109091
  • Larrayoz IM  et al. Transcriptomic profiling explains racial disparities in pterygium patients treated with doxycycline. Invest Ophthalmol Vis Sci 55:7553-61 (2014). WB ; Human . PubMed: 25358733
  • Staudacher I  et al. HERG K+ channel-dependent apoptosis and cell cycle arrest in human glioblastoma cells. PLoS One 9:e88164 (2014). WB ; Human . PubMed: 24516604
  • Shang L  et al. ß-cell dysfunction due to increased ER stress in a stem cell model of Wolfram syndrome. Diabetes 63:923-33 (2014). Human . PubMed: 24227685
  • Lee HC  et al. Zebrafish transgenic line huORFZ is an effective living bioindicator for detecting environmental toxicants. PLoS One 9:e90160 (2014). WB ; Zebrafish . PubMed: 24594581
  • Wang H  et al. Isoflurane induces endoplasmic reticulum stress and caspase activation through ryanodine receptors. Br J Anaesth N/A:N/A (2014). PubMed: 24699520
  • Blas-García A  et al. Lack of mitochondrial toxicity of darunavir, raltegravir and rilpivirine in neurons and hepatocytes: a comparison with efavirenz. J Antimicrob Chemother N/A:N/A (2014). Rat, Human . PubMed: 25011651
  • Yoo JY  et al. Bortezomib-induced unfolded protein response increases oncolytic HSV-1 replication resulting in synergistic antitumor effects. Clin Cancer Res 20:3787-98 (2014). PubMed: 24815720
  • Dalton LE  et al. The endoplasmic reticulum stress marker CHOP predicts survival in malignant mesothelioma. Br J Cancer 108:1340-7 (2013). IHC-P ; Human . PubMed: 23412101
  • Pepping JK  et al. NOX2 deficiency attenuates markers of adiposopathy and brain injury induced by high-fat diet. Am J Physiol Endocrinol Metab 304:E392-404 (2013). Mouse . PubMed: 23233541
  • Kuo DS  et al. Allelic heterogeneity contributes to variability in ocular dysgenesis, myopathy and brain malformations caused by Col4a1 and Col4a2 mutations. Hum Mol Genet N/A:N/A (2013). WB ; Mouse . PubMed: 24203695
  • Hoffman SM  et al. Endoplasmic reticulum stress mediates house dust mite-induced airway epithelial apoptosis and fibrosis. Respir Res 14:141 (2013). WB ; Mouse . PubMed: 24364984
  • Ma T  et al. Suppression of eIF2a kinases alleviates Alzheimer's disease-related plasticity and memory deficits. Nat Neurosci 16:1299-305 (2013). WB ; Mouse . PubMed: 23933749
  • Jehle J  et al. Regulation of apoptosis in HL-1 cardiomyocytes by phosphorylation of the receptor tyrosine kinase EphA2 and protection by lithocholic acid. Br J Pharmacol 167:1563-72 (2012). WB ; Mouse . PubMed: 22845314
  • Manni S  et al. Protein kinase CK2 protects multiple myeloma cells from ER stress-induced apoptosis and from the cytotoxic effect of HSP90 inhibition through regulation of the unfolded protein response. Clin Cancer Res 18:1888-900 (2012). WB . PubMed: 22351691
  • Seyhun E  et al. Tauroursodeoxycholic acid reduces endoplasmic reticulum stress, acinar cell damage, and systemic inflammation in acute pancreatitis. Am J Physiol Gastrointest Liver Physiol 301:G773-82 (2011). PubMed: 21778463
  • Nishina S  et al. Hepatitis C virus protein and iron overload induce hepatic steatosis through the unfolded protein response in mice. Liver Int 30:683-92 (2010). WB ; Mouse . PubMed: 20214734
  • Nagy ZS  et al. Uncoupling JAK3 activation induces apoptosis in human lymphoid cancer cells via regulating critical survival pathways. FEBS Lett 584:1515-20 (2010). WB ; Human . PubMed: 20211620
  • Lenna S  et al. HLA-B35 upregulates endothelin-1 and downregulates endothelial nitric oxide synthase via endoplasmic reticulum stress response in endothelial cells. J Immunol 184:4654-61 (2010). WB ; Human . PubMed: 20335527
  • Kim SJ  et al. Omega-3 and omega-6 fatty acids suppress ER- and oxidative stress in cultured neurons and neuronal progenitor cells from mice lacking PPT1. Neurosci Lett 479:292-6 (2010). WB ; Mouse . PubMed: 20561933
  • Prasanthi JR  et al. Caffeine protects against oxidative stress and Alzheimer's disease-like pathology in rabbit hippocampus induced by cholesterol-enriched diet. Free Radic Biol Med 49:1212-20 (2010). WB ; Rabbit . PubMed: 20638472
  • Malo A  et al. Tauroursodeoxycholic acid reduces endoplasmic reticulum stress, trypsin activation, and acinar cell apoptosis while increasing secretion in rat pancreatic acini. Am J Physiol Gastrointest Liver Physiol 299:G877-86 (2010). WB . PubMed: 20671193
  • Hull RL  et al. Amyloid formation in human IAPP transgenic mouse islets and pancreas, and human pancreas, is not associated with endoplasmic reticulum stress. Diabetologia 52:1102-11 (2009). IHC-P ; Human . PubMed: 19352619
  • Alberti A  et al. ERp46 is reduced by high glucose and regulates insulin content in pancreatic beta-cells. Am J Physiol Endocrinol Metab 297:E812-21 (2009). PubMed: 19622788
  • Weidenfeld-Baranboim K  et al. TRE-dependent transcription activation by JDP2-CHOP10 association. Nucleic Acids Res 36:3608-19 (2008). WB . PubMed: 18463134
  • Haataja L  et al. Many commercially available antibodies for detection of CHOP expression as a marker of endoplasmic reticulum stress fail specificity evaluation. Cell Biochem Biophys 51:105-7 (2008). ICC/IF, WB ; Mouse, Rat . PubMed: 18651105
  • Zenkel M  et al. Impaired cytoprotective mechanisms in eyes with pseudoexfoliation syndrome/glaucoma. Invest Ophthalmol Vis Sci 48:5558-66 (2007). PubMed: 18055805
  • Sarkar D  et al. Activation of double-stranded RNA dependent protein kinase, a new pathway by which human polynucleotide phosphorylase (hPNPase(old-35)) induces apoptosis. Cancer Res 67:7948-53 (2007). PubMed: 17804700
  • Sok J  et al. CHOP-Dependent stress-inducible expression of a novel form of carbonic anhydrase VI. Mol Cell Biol 19:495-504 (1999). PubMed: 9858573
  • Yeager ME  et al. Activation of the unfolded protein response is associated with pulmonary hypertension. Pulm Circ 2:229-40 (0). IHC . PubMed: 22837864

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