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ab11419 has been referenced in 83 publications.

  • Leipnitz G  et al. Evaluation of mitochondrial bioenergetics, dynamics, endoplasmic reticulum-mitochondria crosstalk, and reactive oxygen species in fibroblasts from patients with complex I deficiency. Sci Rep 8:1165 (2018). WB ; Human . PubMed: 29348607
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  • Li PC  et al. Seawater inhalation induces acute lung injury via ROS generation and the endoplasmic reticulum stress pathway. Int J Mol Med 41:2505-2516 (2018). PubMed: 29436612
  • Meng C  et al. PERK Pathway Activation Promotes Intracerebral Hemorrhage Induced Secondary Brain Injury by Inducing Neuronal Apoptosis Both in Vivo and in Vitro. Front Neurosci 12:111 (2018). PubMed: 29541018
  • Lee YL  et al. Epigallocatechin-3-gallate alleviates bladder overactivity in a rat model with metabolic syndrome and ovarian hormone deficiency through mitochondria apoptosis pathways. Sci Rep 8:5358 (2018). PubMed: 29599473
  • Hansson SF  et al. Secretagogin is increased in plasma from type 2 diabetes patients and potentially reflects stress and islet dysfunction. PLoS One 13:e0196601 (2018). PubMed: 29702679
  • Wang Y  et al. GCN2 deficiency ameliorates doxorubicin-induced cardiotoxicity by decreasing cardiomyocyte apoptosis and myocardial oxidative stress. Redox Biol 17:25-34 (2018). PubMed: 29660505
  • Liu J  et al. IRAK2 counterbalances oncogenic Smurf1 in colon cancer cells by dictating ER stress. Cell Signal 48:69-80 (2018). PubMed: 29753111
  • Lei X  et al. Diazoxide inhibits of ER stress-mediated apoptosis during oxygen-glucose deprivation in vitro and cerebral ischemia-reperfusion in vivo. Mol Med Rep 17:8039-8046 (2018). PubMed: 29693708
  • Wei X  et al. GMDS knockdown impairs cell proliferation and survival in human lung adenocarcinoma. BMC Cancer 18:600 (2018). PubMed: 29843634
  • Shu Q  et al. Protective effects of Progranulin against focal cerebral ischemia-reperfusion injury in rats by suppressing endoplasmic reticulum stress and NF-?B activation in reactive astrocytes. J Cell Biochem 119:6584-6597 (2018). PubMed: 29665049
  • Liu S  et al. GCN2 deficiency protects against high fat diet induced hepatic steatosis and insulin resistance in mice. Biochim Biophys Acta Mol Basis Dis N/A:N/A (2018). PubMed: 30006154
  • Martinotti S  et al. (-)- Epigallocatechin-3-gallate induces GRP78 accumulation in the ER and shifts mesothelioma constitutive UPR into proapoptotic ER stress. J Cell Physiol 233:7082-7090 (2018). PubMed: 29744892
  • Xu W  et al. Apelin-13 Alleviates Early Brain Injury after Subarachnoid Hemorrhage via Suppression of Endoplasmic Reticulum Stress-mediated Apoptosis and Blood-Brain Barrier Disruption: Possible Involvement of ATF6/CHOP Pathway. Neuroscience 388:284-296 (2018). PubMed: 30036660
  • Xu L  et al. Bcl-2 overexpression reduces cisplatin cytotoxicity by decreasing ER-mitochondrial Ca2+ signaling in SKOV3 cells. Oncol Rep 39:985-992 (2018). PubMed: 29286126
  • Cheng F  et al. Synergistic neuroprotective effects of Geniposide and ursodeoxycholic acid in hypoxia-reoxygenation injury in SH-SY5Y cells. Exp Ther Med 15:320-326 (2018). PubMed: 29375691
  • Sun X  et al. Neuritin Attenuates Neuronal Apoptosis Mediated by Endoplasmic Reticulum Stress In Vitro. Neurochem Res 43:1383-1391 (2018). PubMed: 29790068
  • Du L  et al. eNOS/iNOS and endoplasmic reticulum stress-induced apoptosis in the placentas of patients with preeclampsia. J Hum Hypertens 31:49-55 (2017). PubMed: 27030287
  • Hu HJ  et al. Protective effects of hydrogen sulfide against angiotensin II-induced endoplasmic reticulum stress in HUVECs. Mol Med Rep 15:2213-2222 (2017). PubMed: 28259956
  • Hammad AS  et al. Structure-activity relationship of piperine and its synthetic amide analogs for therapeutic potential to prevent experimentally induced ER stress in vitro. Cell Stress Chaperones 22:417-428 (2017). PubMed: 28397086
  • Oteng AB  et al. Feeding Angptl4-/- mice trans fat promotes foam cell formation in mesenteric lymph nodes without leading to ascites. J Lipid Res 58:1100-1113 (2017). PubMed: 28412693
  • Wang G  et al. The novel autophagy inhibitor elaiophylin exerts antitumor activity against multiple myeloma with mutant TP53 in part through endoplasmic reticulum stress-induced apoptosis. Cancer Biol Ther 18:584-595 (2017). PubMed: 28718729
  • Stewart C  et al. Regulation of IRE1a by the small molecule inhibitor 4µ8c in hepatoma cells. Endoplasmic Reticulum Stress Dis 4:1-10 (2017). PubMed: 29098149
  • López I  et al. p53-mediated suppression of BiP triggers BIK-induced apoptosis during prolonged endoplasmic reticulum stress. Cell Death Differ 24:1717-1729 (2017). WB . PubMed: 28622297
  • Takahashi N  et al. Activation of Endoplasmic Reticulum Stress in Granulosa Cells from Patients with Polycystic Ovary Syndrome Contributes to Ovarian Fibrosis. Sci Rep 7:10824 (2017). IHC-P ; Mouse, Human . PubMed: 28883502
  • Gan L  et al. Reduced Endoplasmic Reticulum Stress-Mediated Autophagy Is Required for Leptin Alleviating Inflammation in Adipose Tissue. Front Immunol 8:1507 (2017). PubMed: 29250056
  • Wang MG  et al. CaMKII is involved in subcellular Ca2+redistribution-induced endoplasmic reticulum stress leading to apoptosis in primary cultures of rat proximal tubular cells exposed to lead. Oncotarget 8:91162-91173 (2017). PubMed: 29207633
  • Qie X  et al. Endoplasmic Reticulum Stress Mediates Methamphetamine-Induced Blood-Brain Barrier Damage. Front Pharmacol 8:639 (2017). PubMed: 28959203
  • Bu LJ  et al. Melatonin, a novel selective ATF-6 inhibitor, induces human hepatoma cell apoptosis through COX-2 downregulation. World J Gastroenterol 23:986-998 (2017). PubMed: 28246472
  • Liu J  et al. A critical role of DDRGK1 in endoplasmic reticulum homoeostasis via regulation of IRE1a stability. Nat Commun 8:14186 (2017). PubMed: 28128204
  • Wang X  et al. Lyn kinase represses mucus hypersecretion by regulating IL-13-induced endoplasmic reticulum stress in asthma. EBioMedicine 15:137-149 (2017). WB, IHC-P ; Mouse, Human . PubMed: 28024734
  • Wu Z  et al. Silencing of both ATF4 and PERK inhibits cell cycle progression and promotes the apoptosis of differentiating chondrocytes. Int J Mol Med 40:101-111 (2017). WB, IHC ; Mouse . PubMed: 28498443
  • Zhang Z  et al. Homocysteine Induces Apoptosis of Human Umbilical Vein Endothelial Cells via Mitochondrial Dysfunction and Endoplasmic Reticulum Stress. Oxid Med Cell Longev 2017:5736506 (2017). WB ; Human . PubMed: 28630659
  • Li P  et al. Uric acid enhances PKC-dependent eNOS phosphorylation and mediates cellular ER stress: A mechanism for uric acid-induced endothelial dysfunction. Int J Mol Med 37:989-97 (2016). PubMed: 26935704
  • Bao W  et al. Induction of autophagy by the MG-132 proteasome inhibitor is associated with endoplasmic reticulum stress in MCF-7 cells. Mol Med Rep 13:796-804 (2016). PubMed: 26648402
  • Ulbrich L  et al. Autism-associated R451C mutation in neuroligin3 leads to activation of the unfolded protein response in a PC12 Tet-On inducible system. Biochem J 473:423-34 (2016). WB, ICC/IF ; Rat . PubMed: 26621873
  • Sun XY  et al. Valproate attenuates diabetic nephropathy through inhibition of endoplasmic reticulum stress-induced apoptosis. Mol Med Rep 13:661-8 (2016). WB, IHC-P ; Rat . PubMed: 26647757
  • Shen L  et al. Calcium efflux from the endoplasmic reticulum regulates cisplatin-induced apoptosis in human cervical cancer HeLa cells. Oncol Lett 11:2411-2419 (2016). Human . PubMed: 27073489
  • Ding Y  et al. A modifier screen identifies DNAJB6 as a cardiomyopathy susceptibility gene. JCI Insight 1:N/A (2016). WB ; Human . PubMed: 27642634
  • Zhang S  et al. Novel Role of ER Stress and Autophagy in Microcystin-LR Induced Apoptosis in Chinese Hamster Ovary Cells. Front Physiol 7:527 (2016). WB ; Chinese hamster . PubMed: 27877136
  • Zhou X  et al. Propofol Decreases Endoplasmic Reticulum Stress-Mediated Apoptosis in Retinal Pigment Epithelial Cells. PLoS One 11:e0157590 (2016). PubMed: 27311010
  • Xu Y  et al. Myricetin induces apoptosis via endoplasmic reticulum stress and DNA double-strand breaks in human ovarian cancer cells. Mol Med Rep 13:2094-100 (2016). WB . PubMed: 26782830
  • Kong S  et al. Multi-transgenic minipig models exhibiting potential for hepatic insulin resistance and pancreatic apoptosis. Mol Med Rep 13:669-80 (2016). WB . PubMed: 26648014
  • Pang XX  et al. Urotensin II Induces ER Stress and EMT and Increase Extracellular Matrix Production in Renal Tubular Epithelial Cell in Early Diabetic Mice. Kidney Blood Press Res 41:434-49 (2016). PubMed: 27467277
  • Xie Q  et al. ABT737 reverses cisplatin resistance by regulating ER-mitochondria Ca2+ signal transduction in human ovarian cancer cells. Int J Oncol 49:2507-2519 (2016). PubMed: 27748803
  • Christensen DP  et al. Reciprocal signals between microglia and neurons regulate a-synuclein secretion by exophagy through a neuronal cJUN-N-terminal kinase-signaling axis. J Neuroinflammation 13:59 (2016). PubMed: 26957005
  • Zhuang J  et al. Signal transducer and activator of transcription 3 regulates CCAAT-enhancer-binding homologous protein expression in osteoblasts through upregulation of microRNA-205. Exp Ther Med 10:295-299 (2015). PubMed: 26170952
  • Kang JQ  et al. The human epilepsy mutation GABRG2(Q390X) causes chronic subunit accumulation and neurodegeneration. Nat Neurosci 18:988-96 (2015). PubMed: 26005849
  • Kien CL  et al. Lipidomic evidence that lowering the typical dietary palmitate to oleate ratio in humans decreases the leukocyte production of proinflammatory cytokines and muscle expression of redox-sensitive genes. J Nutr Biochem 26:1599-606 (2015). WB . PubMed: 26324406
  • Greenwood M  et al. Transcription Factor CREB3L1 Regulates Endoplasmic Reticulum Stress Response Genes in the Osmotically Challenged Rat Hypothalamus. PLoS One 10:e0124956 (2015). Rat . PubMed: 25915053
  • Varadarajan S  et al. The transrepression arm of glucocorticoid receptor signaling is protective in mutant huntingtin-mediated neurodegeneration. Cell Death Differ 22:1388-96 (2015). PubMed: 25656655
  • Nadeau MÈ  et al. Pharmacological targeting of valosin containing protein (VCP) induces DNA damage and selectively kills canine lymphoma cells. BMC Cancer 15:479 (2015). WB ; Dog . PubMed: 26104798
  • Liu KM  et al. Ketamine-induced ulcerative cystitis and bladder apoptosis involve oxidative stress mediated by mitochondria and the endoplasmic reticulum. Am J Physiol Renal Physiol 309:F318-31 (2015). WB, IF ; Rat . PubMed: 26109091
  • Larrayoz IM  et al. Transcriptomic profiling explains racial disparities in pterygium patients treated with doxycycline. Invest Ophthalmol Vis Sci 55:7553-61 (2014). WB ; Human . PubMed: 25358733
  • Staudacher I  et al. HERG K+ channel-dependent apoptosis and cell cycle arrest in human glioblastoma cells. PLoS One 9:e88164 (2014). WB ; Human . PubMed: 24516604
  • Shang L  et al. ß-cell dysfunction due to increased ER stress in a stem cell model of Wolfram syndrome. Diabetes 63:923-33 (2014). Human . PubMed: 24227685
  • Lee HC  et al. Zebrafish transgenic line huORFZ is an effective living bioindicator for detecting environmental toxicants. PLoS One 9:e90160 (2014). WB ; Zebrafish . PubMed: 24594581
  • Wang H  et al. Isoflurane induces endoplasmic reticulum stress and caspase activation through ryanodine receptors. Br J Anaesth N/A:N/A (2014). PubMed: 24699520
  • Blas-García A  et al. Lack of mitochondrial toxicity of darunavir, raltegravir and rilpivirine in neurons and hepatocytes: a comparison with efavirenz. J Antimicrob Chemother N/A:N/A (2014). Rat, Human . PubMed: 25011651
  • Yoo JY  et al. Bortezomib-induced unfolded protein response increases oncolytic HSV-1 replication resulting in synergistic antitumor effects. Clin Cancer Res 20:3787-98 (2014). PubMed: 24815720
  • Dalton LE  et al. The endoplasmic reticulum stress marker CHOP predicts survival in malignant mesothelioma. Br J Cancer 108:1340-7 (2013). IHC-P ; Human . PubMed: 23412101
  • Pepping JK  et al. NOX2 deficiency attenuates markers of adiposopathy and brain injury induced by high-fat diet. Am J Physiol Endocrinol Metab 304:E392-404 (2013). Mouse . PubMed: 23233541
  • Kuo DS  et al. Allelic heterogeneity contributes to variability in ocular dysgenesis, myopathy and brain malformations caused by Col4a1 and Col4a2 mutations. Hum Mol Genet N/A:N/A (2013). WB ; Mouse . PubMed: 24203695
  • Hoffman SM  et al. Endoplasmic reticulum stress mediates house dust mite-induced airway epithelial apoptosis and fibrosis. Respir Res 14:141 (2013). WB ; Mouse . PubMed: 24364984
  • Ma T  et al. Suppression of eIF2a kinases alleviates Alzheimer's disease-related plasticity and memory deficits. Nat Neurosci 16:1299-305 (2013). WB ; Mouse . PubMed: 23933749
  • Jehle J  et al. Regulation of apoptosis in HL-1 cardiomyocytes by phosphorylation of the receptor tyrosine kinase EphA2 and protection by lithocholic acid. Br J Pharmacol 167:1563-72 (2012). WB ; Mouse . PubMed: 22845314
  • Manni S  et al. Protein kinase CK2 protects multiple myeloma cells from ER stress-induced apoptosis and from the cytotoxic effect of HSP90 inhibition through regulation of the unfolded protein response. Clin Cancer Res 18:1888-900 (2012). WB . PubMed: 22351691
  • Seyhun E  et al. Tauroursodeoxycholic acid reduces endoplasmic reticulum stress, acinar cell damage, and systemic inflammation in acute pancreatitis. Am J Physiol Gastrointest Liver Physiol 301:G773-82 (2011). PubMed: 21778463
  • Nishina S  et al. Hepatitis C virus protein and iron overload induce hepatic steatosis through the unfolded protein response in mice. Liver Int 30:683-92 (2010). WB ; Mouse . PubMed: 20214734
  • Nagy ZS  et al. Uncoupling JAK3 activation induces apoptosis in human lymphoid cancer cells via regulating critical survival pathways. FEBS Lett 584:1515-20 (2010). WB ; Human . PubMed: 20211620
  • Lenna S  et al. HLA-B35 upregulates endothelin-1 and downregulates endothelial nitric oxide synthase via endoplasmic reticulum stress response in endothelial cells. J Immunol 184:4654-61 (2010). WB ; Human . PubMed: 20335527
  • Kim SJ  et al. Omega-3 and omega-6 fatty acids suppress ER- and oxidative stress in cultured neurons and neuronal progenitor cells from mice lacking PPT1. Neurosci Lett 479:292-6 (2010). WB ; Mouse . PubMed: 20561933
  • Prasanthi JR  et al. Caffeine protects against oxidative stress and Alzheimer's disease-like pathology in rabbit hippocampus induced by cholesterol-enriched diet. Free Radic Biol Med 49:1212-20 (2010). WB ; Rabbit . PubMed: 20638472
  • Malo A  et al. Tauroursodeoxycholic acid reduces endoplasmic reticulum stress, trypsin activation, and acinar cell apoptosis while increasing secretion in rat pancreatic acini. Am J Physiol Gastrointest Liver Physiol 299:G877-86 (2010). WB . PubMed: 20671193
  • Hull RL  et al. Amyloid formation in human IAPP transgenic mouse islets and pancreas, and human pancreas, is not associated with endoplasmic reticulum stress. Diabetologia 52:1102-11 (2009). IHC-P ; Human . PubMed: 19352619
  • Alberti A  et al. ERp46 is reduced by high glucose and regulates insulin content in pancreatic beta-cells. Am J Physiol Endocrinol Metab 297:E812-21 (2009). PubMed: 19622788
  • Weidenfeld-Baranboim K  et al. TRE-dependent transcription activation by JDP2-CHOP10 association. Nucleic Acids Res 36:3608-19 (2008). WB . PubMed: 18463134
  • Haataja L  et al. Many commercially available antibodies for detection of CHOP expression as a marker of endoplasmic reticulum stress fail specificity evaluation. Cell Biochem Biophys 51:105-7 (2008). ICC/IF, WB ; Mouse, Rat . PubMed: 18651105
  • Zenkel M  et al. Impaired cytoprotective mechanisms in eyes with pseudoexfoliation syndrome/glaucoma. Invest Ophthalmol Vis Sci 48:5558-66 (2007). PubMed: 18055805
  • Sarkar D  et al. Activation of double-stranded RNA dependent protein kinase, a new pathway by which human polynucleotide phosphorylase (hPNPase(old-35)) induces apoptosis. Cancer Res 67:7948-53 (2007). PubMed: 17804700
  • Sok J  et al. CHOP-Dependent stress-inducible expression of a novel form of carbonic anhydrase VI. Mol Cell Biol 19:495-504 (1999). PubMed: 9858573
  • Yeager ME  et al. Activation of the unfolded protein response is associated with pulmonary hypertension. Pulm Circ 2:229-40 (0). IHC . PubMed: 22837864

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