Product nameDecamethonium bromide, Nicotinic AChR partial agonist
DescriptionNicotinic AChR partial agonist and neuromuscular blocking agent.
- Decamethylene bis(trimethylammonium bromide
Short acting depolarizing muscle relaxant and neuromuscular blocking agent. Used in anesthesia to induce paralysis. Acts as a partial agonist of the nicotinic acetylcholine receptor (AChR). Causes depolarization in the motor endplate, preventing further effects to the normal release of acetylcholine from the presynaptic terminal, and therefore preventing the neural stimulus from affecting the muscle. In the process of binding, decamethonium actually activates (depolarizes) the motor endplate, but since the it is not degraded, the membrane remains depolarized and unresponsive to normal acetylcholine release.
Chemical nameN1,N1,N1,N10,N10,N10-Hexamethyl-1,10-decanediaminium bromide
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 75 mM, in water to 100 mM and in ethanol to 50 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
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This product has been referenced in:
- Lee C & Jones T Molecular conformation-activity relationship of decamethonium congeners. Br J Anaesth 88:692-9 (2002). Read more (PubMed: 12067008) »
- Bertrand D et al. Activation and blocking of neuronal nicotinic acetylcholine receptor reconstituted in Xenopus oocytes. Proc Natl Acad Sci U S A 87:1993-7 (1990). Read more (PubMed: 1968642) »
- FABIAN LW & SHAFER CW Experimental evaluation of a new decamethonium bromide antagonist; a preliminary report. South Med J 47:93-7 (1954). Read more (PubMed: 13135675) »
- FOLDES FF & MACHAJ TS Syncurine (decamethonium-bromide): its use with pentothal-sodium and nitrous oxide-oxygen anesthesia in abdominal surgery. Anesthesiology 12:366-75 (1951). Read more (PubMed: 14838353) »