Decamethonium bromide, Nicotinic AChR partial agonist (ab145744)

Overview

  • Product name

    Decamethonium bromide, Nicotinic AChR partial agonist
  • Description

    Nicotinic AChR partial agonist and neuromuscular blocking agent.
  • Alternative names

    • Decacuran
    • Decamethonum
    • Decamethylene bis(trimethylammonium bromide
    • Decane-1,10-bis(trimethylammonium bromide)
    • Syncurine
    see all
  • Biological description

    Short acting depolarizing muscle relaxant and neuromuscular blocking agent. Used in anesthesia to induce paralysis. Acts as a partial agonist of the nicotinic acetylcholine receptor (AChR). Causes depolarization in the motor endplate, preventing further effects to the normal release of acetylcholine from the presynaptic terminal, and therefore preventing the neural stimulus from affecting the muscle. In the process of binding, decamethonium actually activates (depolarizes) the motor endplate, but since the it is not degraded, the membrane remains depolarized and unresponsive to normal acetylcholine release.

  • CAS Number

    541-22-0
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    N1,N1,N1,N10,N10,N10-Hexamethyl-1,10-decanediaminium bromide
  • Molecular weight

    418.29
  • Molecular formula

    C16H38Br2N2
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 75 mM, in water to 100 mM and in ethanol to 50 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Toxic, refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:

  • Lee C & Jones T Molecular conformation-activity relationship of decamethonium congeners. Br J Anaesth 88:692-9 (2002). Read more (PubMed: 12067008) »
  • Bertrand D  et al. Activation and blocking of neuronal nicotinic acetylcholine receptor reconstituted in Xenopus oocytes. Proc Natl Acad Sci U S A 87:1993-7 (1990). Read more (PubMed: 1968642) »
  • FABIAN LW & SHAFER CW Experimental evaluation of a new decamethonium bromide antagonist; a preliminary report. South Med J 47:93-7 (1954). Read more (PubMed: 13135675) »
  • FOLDES FF & MACHAJ TS Syncurine (decamethonium-bromide): its use with pentothal-sodium and nitrous oxide-oxygen anesthesia in abdominal surgery. Anesthesiology 12:366-75 (1951). Read more (PubMed: 14838353) »

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