Product nameDecamethonium bromide, Nicotinic AChR partial agonist
DescriptionNicotinic AChR partial agonist and neuromuscular blocking agent.
- Decamethylene bis(trimethylammonium bromide
Short acting depolarizing muscle relaxant and neuromuscular blocking agent. Used in anesthesia to induce paralysis. Acts as a partial agonist of the nicotinic acetylcholine receptor (AChR). Causes depolarization in the motor endplate, preventing further effects to the normal release of acetylcholine from the presynaptic terminal, and therefore preventing the neural stimulus from affecting the muscle. In the process of binding, decamethonium actually activates (depolarizes) the motor endplate, but since the it is not degraded, the membrane remains depolarized and unresponsive to normal acetylcholine release.
Chemical nameN1,N1,N1,N10,N10,N10-Hexamethyl-1,10-decanediaminium bromide
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 75 mM, in water to 100 mM and in ethanol to 50 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab145744 has not yet been referenced specifically in any publications.