Overview

  • Product name

  • Description

    Rabbit polyclonal to Decorin
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, ICC/IFmore details
  • Species reactivity

    Reacts with: Mouse, Human
    Predicted to work with: Rabbit, Cow, Dog, Pig
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 147-345 of Human Decorin (Uniprot ID: P07585).

  • Positive control

    • Recombinant Human Decorin protein (ab132145) can be used as a positive control in WB. 293T and Mouse heart cell lysates; paraformaldehyde fixed A549 cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab137508 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 40 kDa.
ICC/IF 1/100 - 1/1000.

Target

  • Function

    May affect the rate of fibrils formation.
  • Involvement in disease

    Defects in DCN are the cause of congenital stromal corneal dystrophy (CSCD) [MIM:610048]. Corneal dystrophies are inherited, bilateral, primary alterations of the cornea that are not associated with prior inflammation or secondary to systemic disease. Most show autosomal dominant inheritance.
  • Sequence similarities

    Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
    Contains 12 LRR (leucine-rich) repeats.
  • Post-translational
    modifications

    The attached glycosaminoglycan chain can be either chondroitin sulfate or dermatan sulfate depending upon the tissue of origin.
  • Cellular localization

    Secreted > extracellular space > extracellular matrix.
  • Information by UniProt
  • Database links

  • Alternative names

    • Bone proteoglycan II antibody
    • CSCD antibody
    • DCN antibody
    • DCN protein antibody
    • Decorin antibody
    • Decorin proteoglycan antibody
    • Dermatan sulphate proteoglycans II antibody
    • DKFZp686J19238 antibody
    • DSPG 2 antibody
    • DSPG2 antibody
    • PG 40 antibody
    • PG II antibody
    • PG S2 antibody
    • PG-S2 antibody
    • PG40 antibody
    • PGII antibody
    • PGS 2 antibody
    • PGS2 antibody
    • PGS2_HUMAN antibody
    • Proteoglycan core protein antibody
    • SLRR1B antibody
    • Small leucine rich protein 1B antibody
    see all

Images

  • Anti-Decorin antibody (ab137508) at 1/500 dilution + 293T whole cell lysate at 30 µg

    Predicted band size: 40 kDa



    10% SDS PAGE
  • Anti-Decorin antibody (ab137508) at 1/1000 dilution + Mouse heart whole cell lysate
    at 50 µg

    Predicted band size: 40 kDa



    12% SDS PAGE
  • Immunofluorescent analysis of paraformaldehyde-fixed A549 cells labelling Decorin, with ab137508 at 1/200 dilution.
    The lower image was merged with DNA probe.

References

This product has been referenced in:

  • Jiang R  et al. Kaempferol protects chondrogenic ATDC5 cells against inflammatory injury triggered by lipopolysaccharide through down-regulating miR-146a. Int Immunopharmacol 69:373-381 (2019). Read more (PubMed: 30776646) »
  • Chu H  et al. Effects of transplanted adipose derived stem cells on the expressions of a-SMA and DCN in fibroblasts of hypertrophic scar tissues in rabbit ears. Exp Ther Med 16:1729-1734 (2018). Read more (PubMed: 30186394) »
See all 5 Publications for this product

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