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Signal Transduction Cytoskeleton / ECM Extracellular Matrix ECM Proteins Collagen
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Anti-Decorin antibody [DCN/3523] (ab268048)

  • Datasheet
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Decorin antibody [DCN/3523] (ab268048)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Decorin antibody [DCN/3523] (ab268048)
  • Protein Array - Anti-Decorin antibody [DCN/3523] (ab268048)

Key features and details

  • Mouse monoclonal [DCN/3523] to Decorin
  • Suitable for: IHC-P, Protein Array
  • Reacts with: Human
  • Isotype: IgG2b

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Secondary
Product image
Goat Anti-Mouse IgG H&L (HRP) (ab205719)

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Overview

  • Product name

    Anti-Decorin antibody [DCN/3523]
    See all Decorin primary antibodies
  • Description

    Mouse monoclonal [DCN/3523] to Decorin
  • Host species

    Mouse
  • Tested applications

    Suitable for: IHC-P, Protein Arraymore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment within Human Decorin aa 212-336. The exact sequence is proprietary.
    Database link: P07585

  • Positive control

    • IHC-P: Human prostate and skin tissue.
  • General notes

    Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

    Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

    We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.

    In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

    We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

    Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

    Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    Preservative: 0.05% Sodium azide
    Constituents: PBS, 0.05% BSA
  • Concentration information loading...
  • Purity

    Protein A/G purified
  • Purification notes

    Purified from Bioreactor concentrate
  • Clonality

    Monoclonal
  • Clone number

    DCN/3523
  • Isotype

    IgG2b
  • Light chain type

    kappa
  • Research areas

    • Signal Transduction
    • Cytoskeleton / ECM
    • Extracellular Matrix
    • ECM Proteins
    • Collagen
    • Signal Transduction
    • Cytoskeleton / ECM
    • Extracellular Matrix
    • Structures
    • Bone
    • Stem Cells
    • Mesenchymal Stem Cells
    • Osteogenesis

Associated products

  • Alternative Versions

    • Anti-Decorin antibody [DCN/3523] - BSA and Azide free (ab268168)
  • Compatible Secondaries

    • Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) (ab150113)
    • Goat Anti-Mouse IgG H&L (HRP) (ab205719)
  • Related Products

    • Recombinant human Decorin protein (ab167743)
    • Recombinant human Decorin protein (ab169898)
    • Recombinant Human Decorin protein (denatured) (ab203550)

Applications

Our Abpromise guarantee covers the use of ab268048 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 1 - 2 µg/ml. Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.

 

 

Protein Array Use at an assay dependent concentration.

Target

  • Function

    May affect the rate of fibrils formation.
  • Involvement in disease

    Defects in DCN are the cause of congenital stromal corneal dystrophy (CSCD) [MIM:610048]. Corneal dystrophies are inherited, bilateral, primary alterations of the cornea that are not associated with prior inflammation or secondary to systemic disease. Most show autosomal dominant inheritance.
  • Sequence similarities

    Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
    Contains 12 LRR (leucine-rich) repeats.
  • Post-translational
    modifications

    The attached glycosaminoglycan chain can be either chondroitin sulfate or dermatan sulfate depending upon the tissue of origin.
  • Cellular localization

    Secreted > extracellular space > extracellular matrix.
  • Target information above from: UniProt accession P07585 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links

    • Entrez Gene: 1634 Human
    • Omim: 125255 Human
    • SwissProt: P07585 Human
    • Unigene: 728830 Human
    • Alternative names

      • Bone proteoglycan II antibody
      • CSCD antibody
      • DCN antibody
      • DCN protein antibody
      • Decorin antibody
      • Decorin proteoglycan antibody
      • Dermatan sulphate proteoglycans II antibody
      • DKFZp686J19238 antibody
      • DSPG 2 antibody
      • DSPG2 antibody
      • PG 40 antibody
      • PG II antibody
      • PG S2 antibody
      • PG-S2 antibody
      • PG40 antibody
      • PGII antibody
      • PGS 2 antibody
      • PGS2 antibody
      • PGS2_HUMAN antibody
      • Proteoglycan core protein antibody
      • SLRR1B antibody
      • Small leucine rich protein 1B antibody
      see all

    Images

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Decorin antibody [DCN/3523] (ab268048)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Decorin antibody [DCN/3523] (ab268048)

      Formalin-fixed, paraffin-embedded human skin tissue stained for Decorin using ab268048 at 2 μg/ml in immunohistochemical analysis.

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Decorin antibody [DCN/3523] (ab268048)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Decorin antibody [DCN/3523] (ab268048)

      Formalin-fixed, paraffin-embedded human prostate tissue stained for Decorin using ab268048 at 2 μg/ml in immunohistochemical analysis.

    • Protein Array - Anti-Decorin antibody [DCN/3523] (ab268048)
      Protein Array - Anti-Decorin antibody [DCN/3523] (ab268048)

      Protein Array containing more than 19,000 full-length human proteins using ab268048. Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (Monoclonal Antibody) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SDs) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SDs) between the Z-score. S-score therefore represents the relative target specificity of a Monoclonal Antibody to its intended target. A Monoclonal Antibody is considered to specific to its intended target, if the Monoclonal Antibody has an S-score of at least 2.5. For example, if a Monoclonal Antibody binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that Monoclonal Antibody to protein X is equal to 29.

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet
  • References (0)

    Publishing research using ab268048? Please let us know so that we can cite the reference in this datasheet.

    ab268048 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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