Overview

  • Product name

    Decoyinine (Augustmycin A), Nucleoside analog
  • Description

    Nucleoside analog. Selective, reversible non-competitive GMP synthetase inhibitor.
  • Biological description

    Nucleoside analog. Selective, reversible non-competitive GMP synthetase inhibitor. Reduces intracellular GDP and GTP levels. Induces sporulation. Shows antitumor effects.
  • Purity

    > 98%
  • CAS Number

    2004-04-8
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (2R,3R,4S)-2-(6-Aminopurin-9-yl)-2-(hydroxymethyl)-5-methylideneoxolane-3,4-diol
  • Molecular weight

    279.25
  • Molecular formula

    C11H13N5O4
  • PubChem identifier

    121578
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water, in DMSO (with warming) and in ethanol
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C=C1[C@H]([C@H]([C@](O1)(CO)N2C=NC3=C2N=CN=C3N)O)O
  • Source

    Streptomyces sp.

  • Research areas

References

This product has been referenced in:

  • Tojo S  et al. Heavy involvement of stringent transcription control depending on the adenine or guanine species of the transcription initiation site in glucose and pyruvate metabolism in Bacillus subtilis. J Bacteriol 192:1573-85 (2010). Read more (PubMed: 20081037) »
  • Nakamura J & Lou L Biochemical characterization of human GMP synthetase. J Biol Chem 270:7347-53 (1995). Read more (PubMed: 7706277) »
  • Hasan A & Srivastava PC Synthesis and biological studies of unsaturated acyclonucleoside analogues of S-adenosyl-L-homocysteine hydrolase inhibitors. J Med Chem 35:1435-9 (1992). Read more (PubMed: 1573637) »

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