Key features and details
- Rabbit polyclonal to Dectin-1
- Suitable for: IHC-P, WB
- Reacts with: Mouse
- Isotype: IgG
Product nameAnti-Dectin-1 antibody
See all Dectin-1 primary antibodies
DescriptionRabbit polyclonal to Dectin-1
Tested applicationsSuitable for: IHC-P, WBmore details
Species reactivityReacts with: Mouse
Predicted to work with: Human
- Mouse spleen tissue; Mouse lung lysate.
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferPreservative: 0.09% Sodium azide
Constituents: 50% Glycerol, 1% BSA
Concentration information loading...
PurityProtein A purified
Our Abpromise guarantee covers the use of ab217331 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||1/100 - 1/500.|
|WB||1/100 - 1/1000. Predicted molecular weight: 28 kDa.|
FunctionLectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and for TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation.
Tissue specificityHighly expressed in peripheral blood leukocytes and dendritic cells. Detected in spleen, bone marrow, lung, muscle, stomach and placenta.
Involvement in diseaseDefects in CLEC7A may be a cause of familial candidiasis type 4 (CANDF4) [MIM:613108]. It is a rare disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans.
Sequence similaritiesContains 1 C-type lectin domain.
modificationsPhosphorylated on tyrosine residues in response to glucan binding.
Cellular localizationCytoplasm and Cell membrane.
- Information by UniProt
- Beta GR antibody
- Beta-glucan receptor antibody
- BGR antibody
Immunohistochemical analysis of formalin-fixed, paraffin-embedded mouse spleen tissue labeling Dectin-1 with ab217331 at 1/200 dilution, followed by secondary antibody detection and DAB staining.
Anti-Dectin-1 antibody (ab217331) at 1/300 dilution + Mouse lung lysate
Goat Anti-Rabbit IgG Antibody (H+L), HRP Conjugated at 1/5000 dilution
Predicted band size: 28 kDa
ab217331 has not yet been referenced specifically in any publications.