Key features and details
- Rat monoclonal [D2.11E4] to DECTIN 2
- Suitable for: IP, IHC-Fr, Flow Cyt
- Reacts with: Mouse
- Isotype: IgG2a
Product nameAnti-DECTIN 2 antibody [D2.11E4]
See all DECTIN 2 primary antibodies
DescriptionRat monoclonal [D2.11E4] to DECTIN 2
Tested applicationsSuitable for: IP, IHC-Fr, Flow Cytmore details
Species reactivityReacts with: Mouse
Predicted to work with: Rat
Recombinant fragment corresponding to Mouse DECTIN 2 aa 44-209 (extracellular). Fused to Fc protein.
IMDQPSRRLYELHTYHSSLTCFSEGTMVSEKMWGCCPNHWKSFGSSCYLI STKENFWSTSEQNCVQMGAHLVVINTEAEQNFITQQLNESLSYFLGLSDP QGNGKWQWIDDTPFSQNVRFWHPHEPNLPEERCVSIVYWNPSKWGWNDVF CDSKHNSICEMKKIYL
Database link: Q9JKF4-1
- IHC-P: Mouse spleen tissue.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferPreservative: 0.09% Sodium azide
Constituent: 99% PBS
Concentration information loading...
PurityProtein G purified
Our Abpromise guarantee covers the use of ab157685 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IP||Use at an assay dependent concentration.|
|IHC-Fr||Use at an assay dependent concentration.|
|Flow Cyt||1/10 - 1/100.
Use 10 µl of the suggested working dilution to label 106cells in 100 µl.
ab18450 - Rat monoclonal IgG2a, is suitable for use as an isotype control with this antibody.
FunctionBinds high-mannose carbohydrates in a Ca(2+)-dependent manner. Functional receptor for alpha-mannans on C.albicans hypheas. Plays an important role in the host defense against C.albicans infection by inducing TH17 cell differentiation. Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses. Transduces signals through an Fc receptor gamma chain /FCER1G and Syk-CARD9-NF-kappa-B-dependent pathway.
Tissue specificityExpressed in lung, spleen, lymph node, leukocytes, bone marrow, tonsils and dendritic cells. Strongly expressed in purified monocytes and weakly in B-cells. In peripheral blood cells, preferentially expressed in plasmacytoids rather than myeloids.
Sequence similaritiesContains 1 C-type lectin domain.
DomainA short stretch of the intracellular domain (AA 8-14) proximal to the transmembrane domain is required for association with Fc receptor gamma chain.
- Information by UniProt
- C type lectin domain family 6 member A antibody
- C type lectin superfamily member 10 antibody
- C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 10 antibody
ab157685 has been referenced in 1 publication.
- Stockman J et al. Adult dogs are capable of regulating calcium balance, with no adverse effects on health, when fed a high-calcium diet. Br J Nutr 117:1235-1243 (2017). PubMed: 28643620