Anti-DEFB-4 antibody [L13-10-D1] (ab14419)
Key features and details
- Mouse monoclonal [L13-10-D1] to DEFB-4
- Suitable for: ELISA, IHC-P, RIA, WB
- Reacts with: Human
- Isotype: IgG1
Overview
-
Product name
Anti-DEFB-4 antibody [L13-10-D1]
See all DEFB-4 primary antibodies -
Description
Mouse monoclonal [L13-10-D1] to DEFB-4 -
Host species
Mouse -
Tested applications
Suitable for: ELISA, IHC-P, RIA, WBmore details -
Species reactivity
Reacts with: Human -
Immunogen
-
Positive control
- IHC-P: Uterus and kidney sections.
-
General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
-
Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
pH: 7.40
Constituent: 0.79% Tris HCl -
Concentration information loading... -
Purity
Protein G purified -
Clonality
Monoclonal -
Clone number
L13-10-D1 -
Isotype
IgG1 -
Research areas
Associated products
-
Compatible Secondaries
-
Immunizing Peptide (Blocking)
-
Isotype control
-
Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab14419 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| ELISA |
Use at an assay dependent concentration.
|
|
| IHC-P | (1) |
Use at an assay dependent concentration.
|
| RIA |
Use at an assay dependent concentration.
|
|
| WB |
Use at an assay dependent concentration. Can be blocked with Recombinant human DEFB-4 protein (ab69499).
|
| Notes |
|---|
|
ELISA
Use at an assay dependent concentration. |
|
IHC-P
Use at an assay dependent concentration. |
|
RIA
Use at an assay dependent concentration. |
|
WB
Use at an assay dependent concentration. Can be blocked with Recombinant human DEFB-4 protein (ab69499). |
Target
-
Function
Has antimicrobial activity. Synergistic effects with lysozyme and DEFB103. -
Tissue specificity
High expression in the testis. Gastric antrum exhibited relatively high levels. A lower expression is observed in uterus and neutrophils thyroid gland, lung, and kidney. No detectable expression in other tissues tested. -
Sequence similarities
Belongs to the beta-defensin family. -
Cellular localization
Secreted. - Information by UniProt
-
Database links
- Entrez Gene: 140596 Human
- Entrez Gene: 503618 Human
- Omim: 602215 Human
- SwissProt: Q8WTQ1 Human
- Unigene: 559507 Human
- Unigene: 730153 Human
-
Alternative names
- BD 4 antibody
- BD-4 antibody
- BD4 antibody
see all
Protocols
Datasheets and documents
-
Datasheet download
References (4)
ab14419 has been referenced in 4 publications.
- Kaulins R et al. Morphofunctional Characterization of Different Tissue Factors in Congenital Diaphragmatic Hernia Affected Tissue. Diagnostics (Basel) 11:N/A (2021). PubMed: 33673194
- Vitenberga Z et al. An Insight into COPD Morphopathogenesis: Chronic Inflammation, Remodeling, and Antimicrobial Defense. Medicina (Kaunas) 55:N/A (2019). PubMed: 31426487
- Dréno B et al. Hidradenitis Suppurativa: The Role of Deficient Cutaneous Innate Immunity. Arch Dermatol : (2011). ICC/IF ; Human . PubMed: 22004878
- Garreis F et al. Roles of human beta-defensins in innate immune defense at the ocular surface: arming and alarming corneal and conjunctival epithelial cells. Histochem Cell Biol 134:59-73 (2010). IHC-P ; Human, Mouse . PubMed: 20526610
