Overview

  • Product name

    Deferiprone, Iron III chelating agent
  • Description

    Iron III chelating agent
  • Biological description

    Iron III chelating agent. Reduces oxidative stress, shows retinal-protective and anti-inflammatory effects in vivo. Orally active.
  • CAS Number

    30652-11-0
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    3-Hydroxy-1,2-dimethylpyridin-4-one
  • Molecular weight

    139.15
  • Molecular formula

    C7H9NO2
  • PubChem identifier

    2972
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 5 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1=C(C(=O)C=CN1C)O3
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Sivakumar S  et al. Protective effects of desferrioxamine and deferiprone on the spleen tissue of aluminum intoxicated mice: A Fourier transform infrared spectroscopy study. Spectrochim Acta A Mol Biomol Spectrosc 126:148-56 (2014). Read more (PubMed: 24594887) »
  • Yatmark P  et al. Iron distribution and histopathological characterization of the liver and heart of ß-thalassemic mice with parenteral iron overload: Effects of deferoxamine and deferiprone. Exp Toxicol Pathol 66:333-43 (2014). Read more (PubMed: 24907196) »
  • Song D  et al. The oral iron chelator deferiprone protects against systemic iron overload-induced retinal degeneration in hepcidin knockout mice. Invest Ophthalmol Vis Sci 55:4525-32 (2014). Read more (PubMed: 24970260) »

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