Overview

  • Product name

    Dehydrocostus lactone, Cell proliferation inhibitor
  • Description

    Cell proliferation inhibitor, induces cell cycle arrest and apoptosis
  • Biological description

    Cell proliferation inhibitor, induces cell cycle arrest and apoptosis. Inhibits NO synthase and TNF-α in LPS-activated macrophages. Cytotoxic T lymphocyte inhibitor in vitro (IC50 = 10 μM). Guaianolide. Immunomodulator and antitumor agent. Active in vivo and in vitro.
  • Purity

    > 98%
  • CAS Number

    477-43-0
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Wang CY  et al. Dehydrocostuslactone suppresses angiogenesis in vitro and in vivo through inhibition of Akt/GSK-3ß and mTOR signaling pathways. PLoS One 7:e31195 (2012). Read more (PubMed: 22359572) »
  • Kuo PL  et al. Dehydrocostuslactone disrupts signal transducers and activators of transcription 3 through up-regulation of suppressor of cytokine signaling in breast cancer cells. Mol Cancer Ther 8:1328-39 (2009). Read more (PubMed: 19383849) »
  • Yuuya S  et al. Guaianolides as immunomodulators. Synthesis and biological activities of dehydrocostus lactone, mokko lactone, eremanthin, and their derivatives. J Nat Prod 62:22-30 (1999). Read more (PubMed: 9917276) »
  • Lee HJ  et al. A sesquiterpene, dehydrocostus lactone, inhibits the expression of inducible nitric oxide synthase and TNF-alpha in LPS-activated macrophages. Planta Med 65:104-8 (1999). Read more (PubMed: 10193198) »
See 1 Publication for this product

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