Key features and details
- Rabbit polyclonal to DEK
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Product nameAnti-DEK antibody
See all DEK primary antibodies
DescriptionRabbit polyclonal to DEK
Tested Applications & Species
Application Species IHC-PHuman
Synthetic peptide corresponding to a region between residue 225 and 275 of Human DEK (NP_003463.1).
- Human Anaplastic Thyroid Carcinoma, Bladder Cell Carcinoma, Breast Carcinoma, Ovarian Carcinoma, Prostate Carcinoma, Skin Squamous Cell Carcinoma and Stomach Adenocarcinoma.
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Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferpH: 6.8
Preservative: 0.09% Sodium azide
Constituents: Tris buffered saline, 0.1% BSA
Concentration information loading...
PurityImmunogen affinity purified
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab85407 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Tested applications are guaranteed to work and covered by our Abpromise guarantee.
Predicted to work for this combination of applications and species but not guaranteed.
Does not work for this combination of applications and species.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
FunctionInvolved in chromatin organization.
Tissue specificityUbiquitous. Expressed at relatively high levels.
Involvement in diseaseA chromosomal aberration involving DEK is found in a subset of acute myeloid leukemia (AML); also known as acute non-lymphocytic leukemia (PubMed:1549122). Translocation t(6;9)(p23;q34) with NUP214/CAN (PubMed:1549122). It results in the formation of a DEK-NUP214 fusion gene (PubMed:1549122).
Sequence similaritiesContains 1 SAP domain.
modificationsPhosphorylated by CK2. Phosphorylation fluctuates during the cell cycle with a moderate peak during G(1) phase, and weakens the binding of DEK to DNA.
Cellular localizationNucleus. Enriched in regions where chromatin is decondensed or sparse in the interphase nuclei.
- Information by UniProt
- D6S231E antibody
- Dek antibody
- DEK gene antibody
ab85407 has not yet been referenced specifically in any publications.