Overview

  • Product name

    Anti-delta 1 Catenin/CAS (phospho S268) antibody - N-terminal
    See all delta 1 Catenin/CAS primary antibodies
  • Description

    Rabbit polyclonal to delta 1 Catenin/CAS (phospho S268) - N-terminal
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow, Rhesus monkey
  • Immunogen

    Synthetic peptide within Human delta 1 Catenin/CAS (N terminal) (phospho S268). The exact sequence is proprietary. Carrier-protein conjugated.
    Database link: O60716

  • Positive control

    • WB: A431 whole cell extract.

Properties

Applications

Our Abpromise guarantee covers the use of ab226774 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000.

Target

  • Function

    Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity). May associate with and regulate the cell adhesion properties of both C- and E-cadherins. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage.
  • Tissue specificity

    Expressed in vascular endothelium.
  • Sequence similarities

    Belongs to the beta-catenin family.
    Contains 10 ARM repeats.
  • Domain

    A possible nuclear localization signal exists in all isoforms where Asp-626--631-Arg are deleted.
  • Post-translational
    modifications

    Phosphorylated by protein-tyrosine kinases. Dephosphorylated by PTPRJ.
  • Cellular localization

    Cytoplasm. Nucleus. Cell membrane. Interaction with GLIS2 promotes nuclear translocation (By similarity). NANOS1 induces its translocation from sites of cell-cell contact to the cytoplasm.
  • Information by UniProt
  • Database links

  • Alternative names

    • Cadherin associated Src substrate antibody
    • Cadherin-associated Src substrate antibody
    • CAS antibody
    • Catenin (cadherin associated protein) delta 1 antibody
    • Catenin delta 1 antibody
    • Catenin delta antibody
    • Catenin delta-1 antibody
    • CTND1_HUMAN antibody
    • CTNND 1 antibody
    • CTNND antibody
    • CTNND1 antibody
    • delta 1 Catenin antibody
    • KIAA0384 antibody
    • p120 antibody
    • P120 CAS antibody
    • p120 catenin antibody
    • P120 CTN antibody
    • p120(cas) antibody
    • p120(ctn) antibody
    • P120CAS antibody
    • P120CTN antibody
    see all

Images

  • All lanes : Anti-delta 1 Catenin/CAS (phospho S268) antibody - N-terminal (ab226774) at 1/1000 dilution

    Lane 1 : A431 (human epidermoid carcinoma cell line) whole cell extract
    Lane 2 : A431 (human epidermoid carcinoma cell line) treated with CIP (calf-intestinal alkaline phosphatase), whole cell extract

    Lysates/proteins at 30 µg per lane.


    7.5% SDS-PAGE gel.

  • All lanes : Anti-delta 1 Catenin/CAS (phospho S268) antibody - N-terminal (ab226774) at 1/3000 dilution

    Lane 1 : A431 (human epidermoid carcinoma cell line) whole cell extract
    Lane 2 : A431 (human epidermoid carcinoma cell line) transfected with delta 1 Catenin shRNA, whole cell extract

    Lysates/proteins at 30 µg per lane.


    7.5% SDS-PAGE gel.

References

ab226774 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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