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Signal Transduction Cytoskeleton / ECM Cytoskeleton Microfilaments Actin etc Catenins
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RabMAb

Anti-delta 1 Catenin/CAS (phospho Y291) antibody [EP2385Y] (ab81274)

  • Datasheet
  • SDS
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Western blot - Anti-delta 1 Catenin/CAS (phospho Y291) antibody [EP2385Y] (ab81274)

    Key features and details

    • Rabbit monoclonal [EP2385Y] to delta 1 Catenin/CAS (phospho Y291)
    • Suitable for: WB
    • Reacts with: Human
    • Isotype: IgG

    You may also be interested in

    Secondary
    Product image
    Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

    View more associated products

    Overview

    • Product name

      Anti-delta 1 Catenin/CAS (phospho Y291) antibody [EP2385Y]
      See all delta 1 Catenin/CAS primary antibodies
    • Description

      Rabbit monoclonal [EP2385Y] to delta 1 Catenin/CAS (phospho Y291)
    • Host species

      Rabbit
    • Tested Applications & Species

      Application Species
      WB
      Human
      See all applications and species data
    • Immunogen

      Synthetic peptide corresponding to Human delta 1 Catenin/CAS (phospho Y291).

    • Positive control

      • Jurkat cell lysate treated with pervanadate
    • General notes

      Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

      Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

    Properties

    • Form

      Liquid
    • Storage instructions

      Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
    • Storage buffer

      pH: 7.20
      Preservative: 0.05% Sodium azide
      Constituents: 0.1% BSA, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, 50% Tissue culture supernatant
    • Concentration information loading...
    • Purity

      Tissue culture supernatant
    • Clonality

      Monoclonal
    • Clone number

      EP2385Y
    • Isotype

      IgG
    • Research areas

      • Signal Transduction
      • Cytoskeleton / ECM
      • Cytoskeleton
      • Microfilaments
      • Actin etc
      • Catenins
      • Stem Cells
      • Signaling Pathways
      • Wnt
      • Cytoplasmic

    Associated products

    • Isotype control

      • Rabbit IgG, monoclonal [EPR25A] - Isotype Control (ab172730)

    Applications

    The Abpromise guarantee

    Our Abpromise guarantee covers the use of ab81274 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Guaranteed

    Tested applications are guaranteed to work and covered by our Abpromise guarantee.

    Predicted

    Predicted to work for this combination of applications and species but not guaranteed.

    Incompatible

    Does not work for this combination of applications and species.

    Application Species
    WB
    Human
    Application Abreviews Notes
    WB
    1/10000 - 1/20000. Predicted molecular weight: 108 kDa.
    Notes
    WB
    1/10000 - 1/20000. Predicted molecular weight: 108 kDa.
  • Application notes
    Is unsuitable for Flow Cyt,ICC/IF,IHC-P or IP.
  • Target

    • Function

      Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity). May associate with and regulate the cell adhesion properties of both C- and E-cadherins. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage.
    • Tissue specificity

      Expressed in vascular endothelium.
    • Sequence similarities

      Belongs to the beta-catenin family.
      Contains 10 ARM repeats.
    • Domain

      A possible nuclear localization signal exists in all isoforms where Asp-626--631-Arg are deleted.
    • Post-translational
      modifications

      Phosphorylated by protein-tyrosine kinases. Dephosphorylated by PTPRJ.
    • Cellular localization

      Cytoplasm. Nucleus. Cell membrane. Interaction with GLIS2 promotes nuclear translocation (By similarity). NANOS1 induces its translocation from sites of cell-cell contact to the cytoplasm.
    • Target information above from: UniProt accession O60716 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links

      • Entrez Gene: 1500 Human
      • Omim: 601045 Human
      • SwissProt: O60716 Human
      • Unigene: 166011 Human
      • Alternative names

        • Cadherin associated Src substrate antibody
        • Cadherin-associated Src substrate antibody
        • CAS antibody
        • Catenin (cadherin associated protein) delta 1 antibody
        • Catenin delta 1 antibody
        • Catenin delta antibody
        • Catenin delta-1 antibody
        • CTND1_HUMAN antibody
        • CTNND 1 antibody
        • CTNND antibody
        • CTNND1 antibody
        • delta 1 Catenin antibody
        • KIAA0384 antibody
        • p120 antibody
        • P120 CAS antibody
        • p120 catenin antibody
        • P120 CTN antibody
        • p120(cas) antibody
        • p120(ctn) antibody
        • P120CAS antibody
        • P120CTN antibody
        see all

      Images

      • Western blot - Anti-delta 1 Catenin/CAS (phospho Y291) antibody [EP2385Y] (ab81274)
        Western blot - Anti-delta 1 Catenin/CAS (phospho Y291) antibody [EP2385Y] (ab81274)
        All lanes : Anti-delta 1 Catenin/CAS (phospho Y291) antibody [EP2385Y] (ab81274) at 1/20000 dilution

        Lane 1 : Jurkat cell lysate untreated
        Lane 2 : Jurkat cell lysate treated with pervanadate

        Lysates/proteins at 10 µg per lane.

        Secondary
        All lanes : HRP labelled goat anti rabbit at 1/2000 dilution

        Predicted band size: 108 kDa
        Observed band size: 108 kDa

      Protocols

      • Western blot protocols

      Click here to view the general protocols

      Datasheets and documents

      • SDS download

      • Datasheet download

        Download

      References (0)

      Publishing research using ab81274? Please let us know so that we can cite the reference in this datasheet.

      ab81274 has not yet been referenced specifically in any publications.

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