Key features and details
- Rabbit polyclonal to Delta Opioid Receptor (phospho S363)
- Suitable for: IHC-P, ELISA
- Reacts with: Human
- Isotype: IgG
Product nameAnti-Delta Opioid Receptor (phospho S363) antibody
See all Delta Opioid Receptor primary antibodies
DescriptionRabbit polyclonal to Delta Opioid Receptor (phospho S363)
SpecificityDetects endogenous levels of Delta Opioid Receptor only when phosphorylated at serine 363
Tested applicationsSuitable for: IHC-P, ELISAmore details
Species reactivityReacts with: Human
Predicted to work with: Mouse
Synthetic phosphopeptide derived from human Delta Opioid Receptor around the phosphorylation site of serine 363 (T-P-SP-D-G).
Storage instructionsShipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
Storage bufferpH: 7.40
Preservative: 0.02% Sodium azide
Constituents: PBS, 50% Glycerol, 0.87% Sodium chloride
Concentration information loading...
PurityImmunogen affinity purified
Purification notesPurified from rabbit antiserum by affinity chromatography using epitope specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Our Abpromise guarantee covers the use of ab62152 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||1/50 - 1/100.|
RelevanceFunction: G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine. Tissue specificity: Detected in oocytes (at protein level). Detected in brain cortex, hypothalamus, hippocampus and olfactory bulb. Detected in oocytes. Similarity: Belongs to the G-protein coupled receptor 1 family. PTM: N-glycosylated. Ubiquitinated. A basal ubiquitination seems not to be related to degradation. Ubiquitination is increased upon formation of OPRM1:OPRD1 oligomers leading to proteasomal degradation; the ubiquitination is diminished by RTP4.
Cellular localizationMulti pass membrane protein
- D-OR-1 antibody
- Delta type opioid receptor antibody
- Delta type opioid receptor DOR 1 antibody
ab62152 has been referenced in 1 publication.
- Byun SW et al. Helicobacter pylori decreases p27 expression through the delta opioid receptor-mediated inhibition of histone acetylation within the p27 promoter. Cancer Lett 326:96-104 (2012). PubMed: 22867947