Demeclocycline hydrochloride, tetracycline antibiotic (ab142277)

Overview

  • Product name

    Demeclocycline hydrochloride, tetracycline antibiotic
  • Description

    Tetracycline antibiotic
  • Biological description

    Tetracycline antibiotic derived from Streptomyces aureofaciens. Binds 30S and 50S ribosomal subunits impairing protein synthesis by bacteria.
  • Purity

    > 85%
  • CAS Number

    64-73-3
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (4S,4aS,5aS,6S,12aR)-7-chloro-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide hydrochloride
  • Molecular weight

    501.30
  • Molecular formula

    C21H21ClN2O8.HCl
  • PubChem identifier

    54686764
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CN(C)C1C2CC3C(C4=C(C=CC(=C4C(=C3C(=O)C2(C(=C(C1=O)C(=O)N)O)O)O)O)Cl)O.Cl
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Jiang SX  et al. Chlortetracycline and demeclocycline inhibit calpains and protect mouse neurons against glutamate toxicity and cerebral ischemia. J Biol Chem 280:33811-8 (2005). Read more (PubMed: 16091365) »
  • Santos MD  et al. Validation of a high-performance liquid chromatographic method for the determination of doxycycline in turkey plasma. J Chromatogr B Biomed Appl 682:301-8 (1996). Read more (PubMed: 8844423) »
  • Hirji MR & Mucklow JC Transepithelial water movement in response to carbamazepine, chlorpropamide and demeclocycline in toad urinary bladder. Br J Pharmacol 104:550-3 (1991). Read more (PubMed: 1797318) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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