Demethoxycurcumin, Natural demethoxy curcuminoid (ab120987)

Overview

  • Product name

    Demethoxycurcumin, Natural demethoxy curcuminoid
  • Description

    Natural demethoxy curcuminoid. Anticancer, antiproliferative and antioxidant activity.
  • Biological description

    Natural demethoxy curcuminoid. Anticancer, antiproliferative and antioxidant activity. Inhibits various signaling pathways including Wnt/β-catenin, AMPK and MAPK.
  • Purity

    > 98%
  • CAS Number

    22608-11-3
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (1E,6E)-1-(4-Hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)-1,6-heptadiene-3,5-dione
  • Molecular weight

    338.36
  • Molecular formula

    C20H18O5
  • PubChem identifier

    5469424
  • Storage instructions

    Store at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions.
  • Solubility overview

    Soluble in DMSO to 100 mM and ethanol to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    Oc1ccc(cc1OC)/C=C/C(=O)CC(=O)/C=C/c2ccc(O)cc2
  • Source

    Curcuma longa

  • Research areas

References

This product has been referenced in:

  • Ni X  et al. Demethoxycurcumin inhibits cell proliferation, migration and invasion in prostate cancer cells. Oncol Rep 28:85-90 (2012). Read more (PubMed: 22552297) »
  • Purkayastha S  et al. Curcumin Blocks Brain Tumor Formation. Brain Res : (2009). Read more (PubMed: 19368804) »
  • Ryu MJ  et al. Natural derivatives of curcumin attenuate the Wnt/beta-catenin pathway through down-regulation of the transcriptional coactivator p300. Biochem Biophys Res Commun 377:1304-8 (2008). Read more (PubMed: 19000900) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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