Overview

  • Product name
    DENN peptide

Description

  • Nature
    Synthetic

Specifications

Our Abpromise guarantee covers the use of ab8384 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    PBS with 0.1% BSA 0.02% sodium azide pH7.2

General Info

  • Alternative names
    • Differentially expressed in normal and neoplastic cells
    • FLJ35600
    • IG20
    • Insulinoma glucagonoma clone 20
    • KIAA0358
    • MADD
    • MADD_HUMAN
    • MAP kinase-activating death domain protein
    • Rab3 GDP/GTP exchange factor
    • RAB3GEP
    see all
  • Function
    Plays a significant role in regulating cell proliferation, survival and death through alternative mRNA splicing. Isoform 5 shows increased cell proliferation and isoform 2 shows decreased. Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms. Component of the TNFRSF1A signaling complex: MADD links TNFRSF1A with MAP kinase activation. Plays an important regulatory role in physiological cell death (TNF-alpha-induced, caspase-mediated apoptosis); isoform 1 is susceptible to inducing apoptosis, isoform 5 is resistant and isoform 3 and isoform 4 have no effect.
  • Tissue specificity
    Highly expressed in fetal brain and kidney; adult testis, ovary, brain and heart. Isoform 5 is constitutively expressed in all tissues. Isoform 7 is expressed in fetal liver and in several cancer cell lines.
  • Sequence similarities
    Belongs to the MADD family.
    Contains 1 dDENN domain.
    Contains 1 death domain.
    Contains 1 DENN domain.
    Contains 1 uDENN domain.
  • Cellular localization
    Membrane.
  • Information by UniProt

References

ab8384 has not yet been referenced specifically in any publications.

Publishing research using ab8384? Please let us know so that we can cite the reference in this datasheet.

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