Anti-DENTT antibody (ab10318)

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Key features and details

  • Rabbit polyclonal to DENTT
  • Reacts with: Human
  • Isotype: IgG

Overview

  • Product name

    Anti-DENTT antibody
    See all DENTT primary antibodies

  • Description

    Rabbit polyclonal to DENTT

  • Host species

    Rabbit

  • Species reactivity

    Reacts with: Human

  • Immunogen

    Full length protein corresponding to Human DENTT.

  • General notes

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing the problem with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation.

    One factor contributing to the crisis is the use of antibodies that are not suitable. This can lead to misleading results and the use of incorrect data informing project assumptions and direction. To help address this challenge, we have introduced an application and species grid on our primary antibody datasheets to make it easy to simplify identification of the right antibody for your needs.

    Learn more here.

Properties

Target

  • Function

    Part of the CASK/TRB1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression.

  • Tissue specificity

    Ubiquitously expressed, with highest levels in brain, testis and heart, and lowest levels in liver and pancreas.

  • Sequence similarities

    Belongs to the nucleosome assembly protein (NAP) family.

  • Post-translational
    modifications

    Phosphorylation at Ser-20 and/or Thr-340 impairs function on cell proliferation.

  • Cellular localization

    Nucleus. Cytoplasm. Enriched in transcriptionally active regions of chromatin in neurons.
  • Information by UniProt

  • Database links

    • Alternative names

      • CASK interacting nucleosome assembly protein antibody
      • CDA1 antibody
      • Cell division autoantigen 1 antibody
      • CINAP antibody
      • CTCL antibody
      • CTCL tumor antigen se20 4 antibody
      • CTCL-associated antigen se20-4 antibody
      • Cutaneous T cell lymphoma associated antigen se20 4 antibody
      • Cutaneous T cell lymphoma associated tumor antigen se20 4 antibody
      • Cutaneous T-cell lymphoma-associated antigen se20-4 antibody
      • Differentially Expressed Nucleolar TGF beta1 Target antibody
      • Differentially Expressed Nucleolar TGF beta1 Target protein antibody
      • Differentially-expressed nucleolar TGF-beta1 target protein antibody
      • HRIHFB2216 antibody
      • NP79 antibody
      • Nuclear protein of 79 kDa antibody
      • RP1 290F12.2 antibody
      • SE20 4 antibody
      • SE204 antibody
      • Testis specific protein Y encoded like 2 antibody
      • testis-specific protein Y encoded-like 2 antibody
      • Testis-specific Y-encoded-like protein 2 antibody
      • TSPX antibody
      • TSPY like 2 antibody
      • TSPY like protein 2 antibody
      • TSPY-like protein 2 antibody
      • TSPYL2 antibody
      • TSYL2_HUMAN antibody
      see all

    References (0)

    Publishing research using ab10318? Please let us know so that we can cite the reference in this datasheet.

    ab10318 has not yet been referenced specifically in any publications.

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