Product nameDeoxycorticosterone acetate, Steroid hormone
DescriptionSteroid hormone used via intramuscular injections in the replacement therapy of the adrenocortical steroid
- 11-Deoxycorticosterone acetate
Steroid hormone commonly used to induce hypertension in experimental animals. This form of hypertension is dependent on altered regulation of central pressor mechanisms including the brain renin-angiotensin system.
Chemical name[2-[(8S,9S,10R,13S,14S,17S)-10,13-Dimethyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 25 mM and in ethanol to 10 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
This product has been referenced in:
- O'Donaughy TL & Brooks VL Deoxycorticosterone acetate-salt rats: hypertension and sympathoexcitation driven by increased NaCl levels. Hypertension 47:680-5 (2006). Read more (PubMed: 16520400) »
- De Nicola AF et al. Effects of deoxycorticosterone acetate (DOCA) and aldosterone on Sar1-angiotensin II binding and angiotensin-converting enzyme binding sites in brain. Cell Mol Neurobiol 13:529-39 (1993). Read more (PubMed: 8111824) »
- Schenk J & McNeill JH The pathogenesis of DOCA-salt hypertension. J Pharmacol Toxicol Methods 27:161-70 (1992). Read more (PubMed: 1498343) »