Deoxycorticosterone acetate, Steroid hormone (ab145812)

Overview

  • Product name

    Deoxycorticosterone acetate, Steroid hormone
  • Description

    Steroid hormone used via intramuscular injections in the replacement therapy of the adrenocortical steroid
  • Alternative names

    • 11-Deoxycorticosterone acetate
    • 21-Acetoxy-4-pregnene-3,20-dione
    • 21-Acetoxyprogesterone
    • 21-Hydroxy-4-pregnene-3,20-dione 21-acetate
    • 21-Hydroxyprogesterone 21-acetate
    • 4-Pregnen-21-ol-3,20-dione 21-acetate
    • Cortexone acetate
    • DOC acetate
    • DOCA
    • Percotol
    see all
  • Biological description

    Steroid hormone commonly used to induce hypertension in experimental animals. This form of hypertension is dependent on altered regulation of central pressor mechanisms including the brain renin-angiotensin system.

  • Purity

    > 99%
  • CAS Number

    56-47-3
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    [2-[(8S,9S,10R,13S,14S,17S)-10,13-Dimethyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate
  • Molecular weight

    372.50
  • Molecular formula

    C23H32O4
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 25 mM and in ethanol to 10 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:

  • O'Donaughy TL & Brooks VL Deoxycorticosterone acetate-salt rats: hypertension and sympathoexcitation driven by increased NaCl levels. Hypertension 47:680-5 (2006). Read more (PubMed: 16520400) »
  • De Nicola AF  et al. Effects of deoxycorticosterone acetate (DOCA) and aldosterone on Sar1-angiotensin II binding and angiotensin-converting enzyme binding sites in brain. Cell Mol Neurobiol 13:529-39 (1993). Read more (PubMed: 8111824) »
  • Schenk J & McNeill JH The pathogenesis of DOCA-salt hypertension. J Pharmacol Toxicol Methods 27:161-70 (1992). Read more (PubMed: 1498343) »

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