Deoxynivalenol (Vomitoxin), Type B trichothecene mycotoxin (ab143487)

Overview

  • Product name

    Deoxynivalenol (Vomitoxin), Type B trichothecene mycotoxin
  • Description

    Type B trichothecene mycotoxin
  • Biological description

    Type B trichothecene mycotoxin. Inhibits protein synthesis. Induces kidney cell DNA methylation. Elevates PYY3-36 and CCK levels. Shows anorectic effects in vivo. Orally active.
  • Purity

    > 98%
  • CAS Number

    51481-10-8
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (3α,7α)-3,7,15-Trihydroxy-12,13-epoxytrichothec-9-en-8-one
  • Molecular weight

    296.32
  • Molecular formula

    C15H20O6
  • PubChem identifier

    40024
  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Toxic, refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1=CC2C(C(C1=O)O)(C3(CC(C(C34CO4)O2)O)C)CO
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Wu W  et al. Role of cholecystokinin in anorexia induction following oral exposure to the 8-ketotrichothecenes deoxynivalenol, 15-acetyldeoxynivalenol, 3-acetyldeoxynivalenol, fusarenon X, and nivalenol. Toxicol Sci 138:278-89 (2014). Read more (PubMed: 24385417) »
  • Akbari P  et al. Deoxynivalenol: a trigger for intestinal integrity breakdown. FASEB J 28:2414-2429 (2014). Read more (PubMed: 24568843) »
  • Kouadio JH  et al. Lipid metabolism disorders, lymphocytes cells death, and renal toxicity induced by very low levels of deoxynivalenol and fumonisin b1 alone or in combination following 7 days oral administration to mice. Toxicol Int 20:218-23 (2013). Read more (PubMed: 24403731) »

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